2C-B

2C-B
Clinical data
Routes of
administration
Oral, insufflation, rectal
Legal status
Legal status
Pharmacokinetic data
Onset of action20–40 min. (Oral)
Elimination half-life2.48 ± 3.20 h[1]
Duration of action4–12 hours depending on route of administration
Identifiers
  • 2-(4-Bromo-2,5-dimethoxyphenyl)ethanamine
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.164.088 Edit this at Wikidata
Chemical and physical data
FormulaC10H14BrNO2
Molar mass260.131 g·mol−1
3D model (JSmol)
  • COc1cc(CCN)c(OC)cc1Br
  • InChI=1S/C10H14BrNO2/c1-13-9-6-8(11)10(14-2)5-7(9)3-4-12/h5-6H,3-4,12H2,1-2H3
  • Key:YMHOBZXQZVXHBM-UHFFFAOYSA-N

2C-B (4-bromo-2,5-dimethoxyphenethylamine) is a synthetic psychedelic drug of the 2C family, mainly used as a recreational drug.[2] The substance was first synthesized by Alexander Shulgin in 1974, and gained an initial reputation for potential psychotherapeutic use, but its use has been limited to mainly recreational use. To date, there is limited scientific information regarding the drug's pharmacokinetics and pharmacological effects in humans. The existing studies primarily classify 2C-B as a stimulant, and hallucinogen, and less commonly as an entactogen, and empathogen.[3]

2C-B, also referred to by a number of slang names, is known to circulate in the illicit market in multiple forms.[4][5] Most commonly found in a powder form, less commonly in capsules or pills. For recreational use, the substance is generally consumed orally or nasally. In Shulgin's book PiHKAL, the dosage range is listed as 12–24 mg.[6]

  1. ^ Papaseit E, Farré M, Pérez-Mañá C, Torrens M, Ventura M, Pujadas M, de la Torre R, González D (2018). "Acute Pharmacological Effects of 2C-B in Humans: An Observational Study". Frontiers in Pharmacology. 9: 206. doi:10.3389/fphar.2018.00206. PMC 5859368. PMID 29593537.
  2. ^ Caudevilla-Gálligo F, Riba J, Ventura M, González D, Farré M, Barbanoj MJ, Bouso JC (July 2012). "4-Bromo-2,5-dimethoxyphenethylamine (2C-B): presence in the recreational drug market in Spain, pattern of use and subjective effects". Journal of Psychopharmacology. 26 (7): 1026–1035. doi:10.1177/0269881111431752. PMID 22234927. S2CID 35535891.
  3. ^ González D, Torrens M, Farré M (2015-10-12). "Acute Effects of the Novel Psychoactive Drug 2C-B on Emotions". BioMed Research International. 2015: 643878. doi:10.1155/2015/643878. PMC 4620274. PMID 26543863.
  4. ^ "2C-B Street Names" (PDF). February 1, 2011. Archived from the original (PDF) on October 16, 2012. Retrieved 2012-09-28.
  5. ^ Westhoff B (2019). Fentanyl, Inc. New York: Atlantic Monthly Press. p. 62. ISBN 978-1-0941-6390-1. OCLC 1136538402.
  6. ^ Shulgin AT (1991). Pihkal : a chemical love story. Ann Shulgin. Berkeley, CA: Transform Press. ISBN 0-9630096-0-5. OCLC 25627628.