Allergen

An allergen is a type of antigen that produces an abnormally vigorous immune response in which the immune system fights off a perceived threat that would otherwise be harmless to the body. Such reactions are called allergies.

In technical terms, an allergen is an antigen that is capable of stimulating a type-I hypersensitivity reaction in atopic individuals through immunoglobulin E (IgE) responses.[1] Most humans mount significant Immunoglobulin E responses only as a defense against parasitic infections. However, some individuals may respond to many common environmental antigens. This hereditary predisposition is called atopy. In atopic individuals, non-parasitic antigens stimulate inappropriate IgE production, leading to type I hypersensitivity.[citation needed]

Sensitivities vary widely from one person (or from one animal) to another. A very broad range of substances can be allergens to sensitive individuals.

  1. ^ Goldsby, Richard A.; et al. Immunology (5th ed.). New York: W.H. Freeman.