U.S. Route 278

U.S. Route 278
US 278 highlighted in red
Route information
Auxiliary route of US 78
Length	1,074 mi[citation needed] (1,728 km)
Existed	1952–present
Major junctions
West end	US 59 / US 71 in Wickes, AR
Major intersections	I-30 in Hope, AR I-55 in Batesville, MS I-22 in Hamilton, AL I-65 in Cullman, AL I-59 in Gadsden, AL I-285 near Atlanta, GA (twice) I-75 / I-85 in Atlanta, GA I-20 in various locations I-520 in Augusta, GA and North Augusta, SC I-95 in Hardeeville, SC
East end	US 278 Bus. in Hilton Head Island, SC
Location
Country	United States
States	Arkansas, Mississippi, Alabama, Georgia, South Carolina
Highway system
United States Numbered Highway System List Special Divided

U.S. Route 278 (US 278) is a parallel route of US 78. It currently runs for 1,074 miles (1,728 km) from Hilton Head Island, South Carolina, to Wickes, Arkansas at US 71/US 59, passing through five states in the process. Landmarks along its route include the Department of Energy's Savannah River Site in South Carolina and the Tennessee-Tombigbee Waterway in eastern Mississippi. There are several universities located along the highway including Georgia State University, the University of Mississippi, and the University of Arkansas at Monticello.