vidarabine


Vidarabine is an analog of adenosine with the D-ribose replaced with D-arabinose. As you can see from figure 1.1 that it is a stereoisomer of adenosine. It has a half-life of 60 minutes, and its solubility is 0.05%, and is able to cross the blood-brain barrier (BBB) when converted to its active metabolite. [5]

Vidarabine ophthalmic side effects. Serious side effects are not expected to occur with the use of this medication. Commonly, some burning, stinging, pain, irritation, itching, redness, blurred vision, tearing, or sensitivity to light may occur. Continue to use vidarabine and talk to your doctor about any side effects that you experience.

Description and Brand Names. Drug information provided by: Merative, Micromedex® US Brand Name. Vira-A; Descriptions. Vidarabine ophthalmic preparations are used to treat virus infections of the eye.

Vidarabine stops replication of herpes viral DNA in 2 ways: 1) competitive inhibition of viral DNA polymerase, and consequently 2) incorporation into and termination of the growing viral DNA chain. Vidarabine is sequentially phosphorylated by kinases to the triphosphate ara-ATP, which is the active form of vidarabine that acts as both an ...

VIRA-A is the trade name for vidarabine (also known as adenine arabinoside and Ara-A), an antiviral drug for the topical treatment of epithelial keratitis caused by Herpes simplex virus. The chemical name is 9H-Purin-6- amine, 9-β-D-arabinofuranosyl-, monohydrate. Each gram of the ophthalmic ointment contains 30 mg of vidarabine monohydrate ...

Vidarabine ophthalmic preparations are used to treat virus infections of the eye. Vidarabine is available only with your doctor's prescription. Before using vidarabine. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make.

After using vidarabine eye ointment, wipe the tip of the ointment tube with a clean tissue and keep the tube tightly closed. Do not use this medicine more often or for a longer time than your doctor ordered. To do so may cause problems in the eyes. If you have any questions about this, check with your doctor.

There is no specific information comparing use of vidarabine in the elderly with use in other age groups. Drug Interactions . Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or ...

The meaning of VIDARABINE is an antiviral agent C10H13N5O4·H2O derived from adenine and arabinoside and used especially to treat keratitis and encephalitis caused by the herpes simplex virus —called also adenine arabinoside, ara-A.

Vidarabine is the first drug to become generally available in the USA for parenteral treatment of life-threatening or debilitating herpes simplex virus infections of man. For the past decade laboratory and clinical studies have been in progress to assess the pharmacology of the compound, its mechani …

Vidarabine (Ophthalmic Route) Your gift holds great power - donate today! Donate. Make your tax-deductible gift and be a part of the cutting-edge research and care that's changing medicine. Donate. Find a doctor. Explore careers. Sign up for free e-newsletters. About Mayo Clinic. About this Site. Contact Us.

Vidarabine. Vidarabine (9-β-d -ribofuranosyladenine; ara-A, adenine arabinoside; Vira-A) is an analogue of adenosine (see Fig. 45-3E) that has in vitro antiviral activity against herpesviruses, poxviruses, rhabdoviruses, and some RNA tumor viruses. Plaque formation by most HSV and VZV strains is completely inhibited by 3 µg/mL or less of ...

Vidarabine | C10H13N5O4 | CID 21704 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety ...

Vidarabine. Vidarabine (9-β-D-arabinofuranosyladenine monohydrate, adenine arabinoside) is a purine nucleoside that is phosphorylated by host cellular enzymes to vidarabine triphosphate. It was originally developed as a cancer chemotherapeutic. Vidarabine triphosphate disrupts DNA synthesis by interfering with DNA polymerase.

Vidarabine (adenine arabinoside) is the stereoisomer of adenosine. This analog of a purine nucleoside exhibits selective activity against the herpes virus. The ribose residue is replaced with an arabinose residue. Like acyclovir, it turns into mono-, di-, and triphosphate in cells infected by a virus, thus inhibiting DNA polymerase, and ...

Vidarabine Synonyms : Adenine Arabinoside, Ara-A. Mechanism : Vidarabine, a purine nucleoside, interferes in the early stages of viral DNA synthesis. It is phosphorylated intracellularly to the triphosphate and may also be incorporated into the viral DNA. It is active against Herpes simplex virus types 1 and 2, varicella-zoster virus and ...

Vidarabine has been shown to be mutagenic, teratogenic, and oncogenic in preclinical testing. Hypersensitivity reactions, including pruritus, erythema, ocular pain, and foreign-body sensation, may occur after ocular application. Other reported effects include photophobia, keratitis after exposure to ultraviolet light, and increased lacrimation. ...

Moreover, vidarabine also inhibits sympathetic activation-induced reactive oxygen species (ROS) production in cardiac myocytes. The pivotal role of vidarabine's inhibitory effect on ROS production with regard to its anti-arrhythmic property has also been implied in animal studies. In addition, as expected, vidarabine exerts an inhibitory effect ...

Effect of vidarabine on BO-induced fibrosis in the heart. a Representative images of Masson-trichrome-stained sections of cardiac muscle in the Control (CTRL) (upper left), BO (upper right), vidarabine (V) (lower left) and BO + V; lower right) groups.b The area of fibrosis was significantly increased in the BO group (n = 5), but this increase was blocked in the BO + V group (n = 4).

Vidarabine is an antiviral, active against herpes viruses, poxviruses, rhabdoviruses, hepadnaviruses and some tumour viruses. A 3% ophthalmic ointment Vira-A is used in the treatment of acute keratoconjunctivitis and recurrent superficial keratitis caused by HSV-1 and HSV-2. Vidarabine is also used to treat herpes zoster in AIDS patients ...

9- -D-Arabinofuranosyladenine monohydrate [24356-66-9]. 16 lis 2021 Vidarabine is also used to treat herpes zoster in AIDS patients, reducing formation of lesions and the duration of viral shedding. · Dosing schedule (How to take Vidarabine, an antiviral chemotherapeutic agent shown to have in vitro activity against the herpes group of viruses, was administered to five patients with For herpes simplex encephalitis the recommended duration of therapy is 10 days. Vidarabine, or 9-~-D arabinofuranosyladenine. 28 lut 2020 vidarabine in combination with human immunoglobulin in the treatment of children with adenovirus pneumonia. 0968 · 267. Compound class: Synthetic organic. 2413. A nucleoside antibiotic isolated from Streptomyces antibioticus. It is the monophosphate ester of VIDARABINE. Vidarabine, a purine nucleoside, interferes in the early stages of viral DNA synthesis. Arabinofuranosyladenine. Yijiang Yi, Yan Yuan. FirstsHealth (pharmacology) An antiviral drug C10H13N5O4·H2O, a form of arabinofuranosyladenine, which is active against herpes simplex and varicella zoster viruses. It has some vidarabine is an approved drug (FDA (1976)). They neutralize acids to form salts plus water. (adenine arabinoside, vira-A, ara- Product Description ; Applications, Vidarabine, is an antiviral drug which is active against herpes simplex and varicella zoster viruses. Comment: Vidarabine is an antiviral drug. COA, Spectra & SDS. These data indicate that disseminated Vidarabine, Ara-A (Vira-A®): FDA approval 1976. Vidarabine or 9-β-D-arabinofuranosyladenine (ara-A) is an antiviral drug which is active against herpes simplex and varicella zoster viruses. The exact way that vidarabine works against viruses in the eye is unknown. It is phosphorylated intracellularly to the triphosphate and may 1 lut 2023 Vidarabine ophthalmic preparations are used to treat virus infections of the eye. 24 Title: Vidarabine. When used as a substrate for viral DNA polymerase, Vidarabine triphosphate Micromedex Detailed Consumer Information24-38%2170413 cze 2005 � 330,87�złAntibiotics; Antibacterial: Antibiotics; AntiviralStreptomyces20 sie 2015 � 11 lut 2022 � . Small 16 maj 2023 Semiochemical - vidarabine ; 9-b-D-Arabinofuranosyladenine ; Formula: C10H13N5O4 ; CAS#:, 5536-17-4 ; MW: 267. Vidarabine is available only with your doctor's Vidarabine, also known as Ara-A or adenine arabinoside, is an antiviral medication used to treat viral infections caused by the herpes simplex virus (HSV) D06298 Drug · Vidarabine (JAN); Vidarabine anhydrous; ARA-A; Armes (TN) · C10H13N5O4 · 267. 04, log rank test). It also has antiviral and possibly antineoplastic Vidarabine. It is chemically related to VIDARABINE is an organic compound containing both amine and alcohol substituents. 13 cze 2005 Vidarabine is a synthetic purine nucleoside analogue with in vitro and in vivo inhibitory activity against herpes simplex virus types 1 Vira-A (vidarabine monohydrate) Ophthalmic Ointment is an antiviral medication used to treat eye infections caused by the herpes virus. Arabinofuranosyladenine or adenine arabinoside is a synthetic purine. Name: Vidarabine; Ara-A; Adenine Arabinoside; 9-β-D-Arabinofuranosyladenine. Vidarabine definition: an antiviral substance, C 10 H 15 N 5 O 4 , produced by the bacterium Streptomyces | Meaning, pronunciation, translations and 3 wrz 2019 Vidarabine-TP and fludarabine-TP are potent inhibitors of DNA replication in vivo (25) and have been shown to inhibit both replicative DNA Know about technical details of Vidarabine like: chemical name, chemistry structure, formulation, uses, toxicity, action, side effects and more at in vitro, Vidarabine triphosphate stops replication of herpes viral DNA. It is available for topical Find patient medical information for vidarabine (bulk) on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user VIDARABINE OINTMENT 3% "TOWA" · Effects of this medicine · The following patients may need to be careful when using this medicine. 25 [5536-17-4]. Cat. 096741 Da; ChemSpider ID20400. It acts as a prodrug that, once phosphorylated by cellular enzymes, acts as vidarabine; adenine arabinoside; araadenosine; arabinosyladenine; vidarabin. 2 lip 2020 Abstract What is known and objective Although superseded by other antiviral agents in many Western countries, vidarabine is still widely Vidarabine (adenine arabinoside; ara-A) is an antiviral agent active against DNA viruses but with low toxicity for human cells. Vidarabine is an antiviral drug which is active against herpes simplex and varicella zoster viruses. 241 Da; Monoisotopic mass267. » Vidarabine has a potency equivalent Vidarabine phosphate is an adenosine monophosphate analog. ; References, Sneader, W Most of the drugs in this group are topical preparations. Mode of Action Vidarabine works by interfering with the synthesis of viral DNA. Target: DNA/RNA Synthesis Vidarabine is a nucleoside Acyclovir recipients were discharged from the hospital more promptly than vidarabine recipients (P = . Vidarabine ophthalmic is used to treat eye Vidarabine (adenine arabinoside) is a purine nucleoside useful in humans for therapy of herpes simplex virus encephalitis and herpes zoster virus infections Vidarabine is an analog of the nucleoside adenosine that has antiviral properties. CAS Name: 9-b-D-Arabinofuranosyl-9H-purine-6-amine monohydrate. Systemic preparations with clear ophthalmological indications are also classified in this group. goldbio. Molecular FormulaC10H13N5O4; Average mass267. Anhydrous 267. com/product/13166/adenine-9-beta-d-arabinofuranoside-vidarabine. Amines are chemical bases. Vidarabine is an antiviral drug by interfering with the synthesis of viral DNA, used to treat herpes simplex and varicella zoster viruses. CAS Registry Number: 5536-17-4. defined stereocentres Vidarabine is an antiviral drug by interfering with the synthesis of viral DNA, used to treat herpes simplex and varicella zoster viruses. It is a nucleoside analog and therefore has to be phosphorylated to be Vidarabine is an antiviral medication. Vidarabine is a synthetic purine nucleoside analogue with in vitro and in vivo inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2), and Phosphorylated vidarabine inhibits viral DNA polymerase activity to inhibit viral DNA synthesis, and it inhibits ribonucleoside reductase and several other Vidarabine, an adenosine analog with an altered sugar, is an antiviral agent used for the treatment of herpes and acyclovir-resistant viruses. https://www

Vidarabine or 9-β-D-arabinofuranosyladenine (ara-A) is an antiviral drug which is active against herpes simplex and varicella zoster viruses. In the 1950sanother notch and led to vidarabine vs. aciclovir trials in the late 1980s. The lower toxicity and ease of administration over vidarabine has led to aciclovirVidarabine phosphate is an adenosine monophosphate nucleotide in which ribose is replaces by an arabinso moiety. It has antiviral and possibly antineoplasticPentostatin (or deoxycoformycin, trade name Nipent, manufactured by SuperGen) is an anticancer chemotherapeutic drug. It is classified as a purine analogfamciclovir, valaciclovir for the shingles, zoster-immune globulin (ZIG), and vidarabine. Acyclovir is frequently used as the drug of choice in primary VZV infectionsanticoagulants, such as warfarin (reported rarely, but is serious when it occurs) Vidarabine Chlorpropamide Phenytoin Theophylline Cyclophosphamide, doxorubicin, bleomycin(CMV) Vicriviroc HIV-1 Schering-Plough pyrimidine CCR5 entry inhibitor Vidarabine Herpes Simplex, Varicella Zoster Zalcitabine HIV Zanamivir (Relenza) Influenza Famciclovir, Ganciclovir, Penciclovir, Valaciclovir, Valganciclovir Vidarabine Pyrimidine analogues of uridine: Idoxuridine, Trifluridine Brivudine Mutationsβ-D-Arabinofuranose. They are mostly used as cytostatics or virostatics. Cytarabine Vidarabine Nelarabine Fludarabine Clofarabine Sorivudine Clevudine W. E. Müller:have similar effectiveness but are more effective than Idoxuridine and Vidarabine eye drops. Oral acyclovir is as effective as topical antivirals for treatinganalogue drugs include: deoxyadenosine analogues: didanosine (ddI)(HIV) vidarabine (antiviral) adenosine analogues: galidesivir (Ebola) remdesivirC10H13N5O4 (molar mass: 267.24 g/mol) may refer to: Adenosine Deoxyguanosine Vidarabine, or 9-β-D-arabinofuranosyladenine (ara-A) Zidovudine This set index pageto: Adenosine monophosphate (AMP) Deoxyguanosine monophosphate (dGMP) Vidarabine phosphate This set index page lists chemical structure articles associatedCytarabine (Ara-C) Cytosar-U Sponge Nucleoside DNA Polymerase >50/711 Cancer Vidarabine (Ara-A) Vira-A Sponge Nucleoside Viral DNA Polymerase 0 Antiviral Ziconotidecaused by Herpes simplex virus, antiviral therapy with (acyclovir or vidarabine) must be started immediately for a favorable outcome. Acyclovir is a bettersponge, providing the basis for anti-viral drugs and anti-cancer drugs. Vidarabine, an antiviral drug, was derived from these compounds. The discovery oftrifluridine and aciclovir were a more effective treatment than idoxuridine or vidarabine, significantly increasing the relative number of successfully healed eyesIdoxuridine S01AD02 Trifluridine S01AD03 Aciclovir S01AD05 Interferon S01AD06 Vidarabine S01AD07 Famciclovir S01AD08 Fomivirsen S01AD09 Ganciclovir S01AE01 Ofloxacinmorbidity and mortality are due to the use of antiviral treatments such as vidarabine and acyclovir. However, morbidity and mortality still remain high dueLaboratories) Vicoprin Vicoprofen vicriviroc (USAN) Victoza (Novo Nordisk) vidarabine (INN) Vidaza Videx vidofludimus (INN) vidupiprant (INN) vigabatrin (INN)version. J05AA01 Metisazone J05AB01 Aciclovir J05AB02 Idoxuridine J05AB03 Vidarabine J05AB06 Ganciclovir J05AB09 Famciclovir J05AB11 Valaciclovir J05AB12 Cidofovirknown to inhibit primases are nucleotide analogs such as AraATP (see Vidarabine) and 2-fluoro-AraATP. These compounds will often be used as substratescytarabine MeSH D13.570.065.300.050 – ancitabine MeSH D13.570.065.950 – vidarabine MeSH D13.570.230.229 – deoxyadenosines MeSH D13.570.230.229.075 – cladribine

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