idoxuridine


Idoxuridine is an anti-herpesvirus antiviral drug. It is a nucleoside analogue, a modified form of deoxyuridine, similar enough to be incorporated into viral DNA replication, but the iodine atom added to the uracil component blocks base pairing. It is used only topically due to cardiotoxicity.

Idoxuridine is a pyrimidine analog antiviral used for the treatment of viral eye infections, including herpes simplex keratitis. Generic Name Idoxuridine DrugBank Accession Number DB00249 Background. An analog of deoxyuridine that inhibits viral DNA synthesis. The drug is used as an antiviral agent.

Idoxuridine is a topical antiviral agent that treats eye infections caused by feline herpes virus in cats. Learn about its mechanism of action, potential side-effects, drug interactions, precautions, and dosage instructions.

In chemical structure idoxuridine closely approximates the configuration of thymidine, one of the four building blocks of DNA (the genetic material of the Herpes virus).As a result, idoxuridine is able to replace thymidine in the enzymatic step of viral replication or "growth". The consequent production of faulty DNA results in a pseudostructure which cannot infect or destroy tissue.

Idoxuridine. In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. Organs and systems Sensory systems. Idoxuridine eye-drops are locally toxic, especially in patients with dry eyes, because of increased concentrations (or reduced tear secretion), and can cause local sensitization. Lacrimal punctum stenosis, lacrimation, follicular conjunctivitis, narrowing of meibomian gland orifices ...

Access up-to-date medical information for less than $1 a week. Purchase a subscription I'm already a subscriber. Browse sample topics. Idoxuridine answers are found in the Johns Hopkins ABX Guide powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.

Idoxuridine is the first FDA-approved antiviral drug for herpes simplex keratitis. Learn about its structure, synthesis, applications, and hazards from the CAS database and the ACS website.

Discovered more than fifty years ago, Idoxuridine (15) was the first marketed antiviral nucleoside used for the treatment of the herpes simplex virus. Since then, nucleoside-based treatment regimens have started to emerge as real game-changers in therapeutic settings, especially in the field of oncology and virology.

Idoxuridine. Idoxuridine (5-iodo-2′-deoxyuridine, IDU; Herplex) is an iodinated thymidine analogue (Fig. 45-3C) that inhibits replication of various DNA viruses in vitro, particularly herpesviruses and poxviruses. 451 Plaque production by most clinical isolates of HSV type 1 is inhibited by concentrations of 2 to 10 µg/mL.

Serious side effects have been reported with idoxuridine. See the "Idoxuridine Precautions" section. Common side effects of idoxuridine include the following: eye irritation or pain. redness. itching. swelling of the eye. increased sensitivity to light and glare. This is not a complete list of idoxuridine side effects.

By 1962, Herbert Kaufman had introduced idoxuridine (IDU) to the world as the first antiviral drug to successfully treat a human viral infection: herpes simplex keratitis. 2 For the next decade, idoxuridine was the treatment of choice for epithelial herpes simplex keratitis. However, this was not perfect as it was frequently associated with toxicity, including superficial punctate keratopathy ...

Idoxuridine is an eyedrop that slows the growth of viruses that cause certain eye infections. It is no longer available in the United States and has potential side effects and precautions.

Idoxuridine Uses, Dosage, Side Effects, Food Interaction and all others data. Idoxuridine, a pyrimidine nucleoside structurally related to thymidine, inhibits viral replication by substituting itself for thymidine in viral DNA. It is active against herpes simplex and varicella zoster viruses, and has also been shown to inhibit vaccinia virus ...

The approval of first antiviral drug 'idoxuridine' in June 1963 has opened a new era in antiviral drug development. Since then, number of drugs with antiviral potential have been developed for clinical use for the treatment of millions of human beings worldwide. 4 Antiviral drugs are a class of medicines particularly used for the treatment ...

Idoxuridine is an anti-herpes drug that inhibits viral DNA synthesis by incorporating into viral DNA. It is used as eye drops for HSV keratitis, but can cause irritation and inflammation.

Idoxuridine is an antiviral agent used to treat eye infections caused by the herpes simplex virus. Learn about its uses, side effects, dosage, interactions, and precautions before using it.

Idoxuridine is an analog of timidin—and iodinated derivative of deoxyuridin. Idoxuridine has an effect on viral DNA, and does not have an effect on viral RNA. The primary action of idoxuridine consists of inhibiting viral DNA replication by incorporating right in the DNA itself. Upon systemic introduction, this nucleoside is phosphorylated by ...

IDOXURIDINE powder. NDC Code (s): 86036-016-00, 86036-016-01. Packager: Nanjing Chemlin Biomedical Science & Technology Co, Ltd. Category: BULK INGREDIENT - ANIMAL DRUG. DEA Schedule: None. Marketing Status: Bulk Ingredient For Animal Drug Compounding.

Idoxuridine is an antiviral eye medication for cats, dogs, and horses with herpesvirus infections. Learn how to use it, its side effects, interactions, and precautions.

Idoxuridine, also known by the names Stoxil®, Herplex®, Dendrid®, is often used for cats in the treatment of conjunctival and corneal disease associated with feline herpes virus. A virus is a packet of genetic material, often DNA, surrounded by a viral envelope or membrane. This virus is quite fragile when outside the body but is very ...

Of the drugs discussed in this review, idoxuridine highlights the problem myelosuppression may cause when nucleoside analogues are used as antibiotics. While idoxuridine is used to treat herpetic simplex keratitis of the eye, it has been found to worsen and slow healing of bacterial infections of the eye (Yamaguchi et al., 1979). Thus ...

Idoxuridine (IDU) acts via a similar mechanism as TFU and is similarly toxic if given systemically. However, it has been used as an ophthalmic 0.1% solution or 0.5% ointment. This drug is well tolerated by most cats and seems efficacious in many. It should be applied at least 5-6 times daily.

Idoxuridine and trifluridine are active against FHV-1 in vitro, 43, 55 although both are more active against HSV. 43, 55 In cats with ocular disease attributed to FHV-1, 0.1% idoxuridine solution was used q4-6h with improvement of clinical signs in three cats and no improvement or worsening in four cats. 87 Treatment with 1% trifluridine ...

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Idoxuridine is an anti-herpesvirus antiviral drug. It is a nucleoside analogue, a modified form of deoxyuridine, similar enough to be incorporated intowith herpes of the eye, aciclovir may be more effective and safer than idoxuridine. It is not clear if aciclovir eye drops are more effective than brivudineB) zidovudine (azidothymidine, or AZT)(HIV) deoxyuridine analogues: idoxuridine trifluridine Related drugs are nucleobase analogs, which don't includeshingles). The original compounds used were 5-iodo-2'-deoxyuridine, AKA idoxuridine, IUdR, or(IDU) and 1-β-D-arabinofuranosylcytosine or ara-C, later marketedIbacitabine Herpes labialis Ibalizumab (Trogarzo) HIV Entry inhibitor 2018 Idoxuridine Herpes dU analogue inhibitor 1962 Imiquimod Genital wart, Basal cellcomposition of uridine but without the presence of the 2' hydroxyl group. Idoxuridine and Trifluridine are variants of deoxyuridine used as antiviral drugsTrifluridine eye drops have similar effectiveness but are more effective than Idoxuridine and Vidarabine eye drops. Oral acyclovir is as effective as topical antivirals1974 Nobel Prize in Physiology and Medicine William Prusoff: discovered idoxuridine, the first antiviral agent approved by the U.S. Food and Drug AdministrationExamples include naturally occurring metabolites: drugs: Fluorouracil Idoxuridine Primidone Trifluridine and pesticides: Bromacil Saflufenacil v t eanti-herpetic medications (e.g., acyclovir, famciclovir, ganciclovir, idoxuridine, penciclovir, tromantadine, valaciclovir, or valganciclovir) showed nooxymercuration reactions. A famous use of Hg(OAc)2 was in the synthesis of idoxuridine. Mercuric acetate is a highly toxic compound, due to it being water-solubleThe oldest commercially available technique uses iodo-deoxyuridine (idoxuridine) wherein a methyl group in thymidine has been replaced with radioactiveidenast (INN) Idkit:HP (Exalenz Bioscience) iDose TR idoxifene (INN) idoxuridine (INN) idrabiotaparinux (INN) idralfidine (INN) idramantone (INN) idraparinuxValaciclovir, Valganciclovir Vidarabine Pyrimidine analogues of uridine: Idoxuridine, Trifluridine Brivudine Mutations in the gene coding thymidine kinasepharmacologist who was an early innovator in antiviral drugs, developing idoxuridine, the first antiviral agent approved by the FDA, in the 1950s, and co-developingkeratitis. Brivudine was found to be significantly more effective than idoxuridine in increasing the number of successfully healed eyes of participantsthat trifluridine and aciclovir were a more effective treatment than idoxuridine or vidarabine, significantly increasing the relative number of successfullyS01AB03 Sulfadicramide S01AB04 Sulfacetamide S01AB05 Sulfafenazol S01AD01 Idoxuridine S01AD02 Trifluridine S01AD03 Aciclovir S01AD05 Interferon S01AD06 VidarabineKaufman (September 28, 1931) is an American ophthalmologist who discovered idoxuridine, the first clinically useful antiviral agent; co-developed with WilliamQD06BA90 Formosulfathiazole QD06BA99 Sulfonamides, combinations D06BB01 Idoxuridine D06BB02 Tromantadine D06BB03 Aciclovir D06BB04 Podophyllotoxin D06BB05substrate analogs AZT Stavudine Idoxuridine Aciclovir Ganciclovir Other thymidine analogues, for instance Idoxuridine (ATC: J05AB02) act by blocking baseIrvine-Gass syndrome Herbert E. Kaufman, 1956, ophthalmologist who discovered idoxuridine Joan Miller, 1985, ophthalmologist Perry Rosenthal, non-degreed, ophthalmologistfollows the WHO version. J05AA01 Metisazone J05AB01 Aciclovir J05AB02 Idoxuridine J05AB03 Vidarabine J05AB06 Ganciclovir J05AB09 Famciclovir J05AB11 Valaciclovirmonoclonal antibody – idiopathic – idiopathic myelofibrosis – idoxifene – idoxuridine – ifosfamide – IH636 grape seed extract – IL-1 – IL-1-alfa – IL-11 –bromodeoxyuridine MeSH D13.570.230.430.432 – floxuridine MeSH D13.570.230.430.609 – idoxuridine MeSH D13.570.230.500 – dideoxynucleosides MeSH D13.570.230.500.090 –

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