2-Deoxy-d-glucose is a glucose molecule which has the 2-hydroxyl group replaced by hydrogen, so that it cannot undergo further glycolysis. As such; it acts to competitively inhibit the production of glucose-6-phosphate from glucose at the phosphoglucoisomerase level (step 2 of glycolysis).
The ability of 2-deoxy-d-glucose (2-DG) to interfere with d-glucose metabolism demonstrates that nutrient and energy deprivation is an efficient tool to suppress cancer cell growth and survival.Acting as a d-glucose mimic, 2-DG inhibits glycolysis due to formation and intracellular accumulation of 2-deoxy-d-glucose-6-phosphate (2-DG6P), inhibiting the function of hexokinase and glucose-6 ...
1. Introduction. 2-Deoxy-D-glucose (2-DG, 2-deoxy-D-arabino-hexopyranose) is a natural [], nonmetabolizable glucose analog and a competitive inhibitor of glycolysis [] in which the 2-hydroxyl group is replaced by hydrogen (Figure 1). 2-DG blocks the activity of different enzymes involved in glycolysis, leading to cell death.Hyperglycemic condition aggravates cancer cell proliferation ...
2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP ...
Recently, 2-deoxy-D-glucose (2-DG) has evaluated as a polypharmacological agent for COVID-19 therapy owing to its influence on the glycolytic pathway, interaction with viral proteins, and anti-inflammatory action. In May 2020, the Indian drug regulatory authority approved 2-DG as an emergency adjunct therapy in mild to severe COVID-19 patients ...
This understanding, at least in part, explains the profound effects that the analog of glucose, 2-deoxy-d-glucose, has been shown to have on as common and widespread diseases as cancer, viral infection, aging-related morbidity, epilepsy, and others. This review is confined to summarizing some of the salient findings of this remarkable compound ...
One way to halt such energy-dependent processes is by interfering with the glycolytic pathway. 2-Deoxy-d-glucose (2-DG) is a synthetic glucose analogue that can inhibit key enzymes in the glycolytic pathway. The efficacy of 2-DG has been reported across an array of diseases and disorders, thereby demonstrating its broad therapeutic potential.
2-Deoxy-D-glucose (2DG) has recently received emergency approval for the treatment of COVID-19 in India, after a successful clinical trial. SARS-CoV-2 infection of cultured cells is accompanied by ...
This understanding, at least in part, explains the profound effects that the analog of glucose, 2-deoxy-d-glucose, has been shown to have on as common and widespread diseases as cancer, viral infection, aging-related morbidity, epilepsy, and others. This review is confined to summarizing some of the salient findings of this remarkable compound ...
2-Deoxy-D-Glucose. FDG-PET (fluoro-deoxy-glucose PET) is a form of radionucleotide imaging that measures neuronal glucose uptake as a correlate of brain function. ... 2-Deoxyglucose (2-DG), a derivative of glucose, is able to be phosphorylated by hexokinase, resulting in the formation of 2-deoxyglucose-phosphate (2-DG-P) [89].
2-Deoxy-d-glucose (2-DG) exploits cancer-induced increased glucose uptake and metabolism by blocking glycolysis and interfering with N-linked glycosylation. The major oncogenes involved in converting a normal cell to a tumor cell have been shown to also upregulate glucose uptake and metabolism. As an analog of glucose, 2-DG preferentially ...
Various sugar analogs have been developed to measure glucose uptake 6 (Fig. S1). 2-Deoxy-D-glucose (2DG) and its radiolabeled forms (3 H-2DG and 18 F-FDG) passing through GLUTs provide a reliable ...
2-Deoxy-D-glucose inhibits the phagocytosis of immunoglobulin G, or complement-coated sheep erythrocytes by mouse peritoneal macrophages, but does not inhibit the phagocytosis of latex or zymosan particles by the same cells (15, 16 ). A similar inhibitory effect of this glucose and mannose analog on receptor-mediated phagocytosis by guinea pig ...
2-deoxy-D-glucose is a natural product found in Streptomyces nigra with data available. 2-Deoxy-D-glucose is a non-metabolizable glucose analog in which the hydroxyl group at position 2 of glucose is replaced by hydrogen, with potential glycolysis inhibiting and antineoplastic activities.
The ability of 2-deoxy-d-glucose (2-DG) to interfere with d-glucose metabolism demonstrates that nutrient and energy deprivation is an efficient tool to suppress cancer cell growth and survival. Acting as a d-glucose mimic, 2-DG inhibits glycolysis due to formation and intracellular accumulation of 2-deoxy-d-glucose-6-phosphate (2-DG6P ...
2-deoxy-D-glucose (2-DG) is a modified form of D-glucose. It is synthesized by replacing a hydroxyl group (-OH) with hydrogen on the second carbon of D-glucose. The chemical formula of 2-DG is C 6 H 12 O 5. The conversion of D-glucose to 2-DG is a multi-step process.
Zhang, D. et al. 2-Deoxy-D-glucose targeting of glucose metabolism in cancer cells as a potential therapy. Cancer Lett. 355 , 176-183 (2014). Article CAS Google Scholar
The ability of 2-deoxy-d-glucose (2-DG) to interfere with d-glucose metabolism demonstrates that nutrient and energy deprivation is an efficient tool to suppress cancer cell growth and survival. Acting as a d-glucose mimic, 2-DG inhibits glycolysis due to formation and intracellular accumulation of 2-deoxy-d-glucose-6-phosphate (2-DG6P), inhibiting the function of hexokinase and glucose-6 ...
2-deoxy-D-glucose: Definition A deoxyglucose that is D-glucose in which the hydroxy group at position 2 has been replaced by a hydrogen. It is an antimetabolite of glucose with antiviral activity, which acts by inhibiting the glycosylation of glycoproteins and glycolipids. Used as an antiherpes agent.
Intervention 2-Deoxy-D-Glucose 45 mg/kg body weight AM plus 45 mg/kg body weight PM PLUS Standard of Care for 10 days or until discharge, whichever earlier. Standard of care only For 10 days or until discharge: Primary Outcome: 1. To evaluate the efficacy of 2-Deoxy-D-Glucose (2-DG) as adjunctive therapy to standard of care (SoC), in comparison ...
Glucose and glutamine consumption are increased in mtDNA dysfunction, and so we targeted the use of both in cells carrying the pathogenic m.3243A>G variant with 2-Deoxy-D-glucose (2DG), or the ...
D-Glucose, in its normal form, is known to most of us. Interestingly, just by replacing an -OH group with a hydrogen, we get 2-deoxy-D-glucose (2-DG) which has excellent medicinal properties. An interesting observation related to glycolysis led to the use of 2-DG as an anticancer drug. Recently, there has been sufficient evidence to support the efficacy of 2-DG as an anti-Covid medication.
Glucose is converted to lactate even under sufficient oxygen tension. Interfering with this process may be a potential effective strategy to cause cancer cell death because these cells rely heavily on glucose metabolism for survival and proliferation. 2-Deoxy-D-glucose (2DG), a glucose analog, targets glucose metabolism to deplete cancer cells ...
Objective. To assess the diagnostic performance of 18F-fluoro-2-deoxy-d-glucose (18F-FDG) positron emission tomograpy (PET)/computed tomography (CT) in nodal staging before radical cystectomy (RC) and pelvic lymph node dissection (PLND) for bladder cancer (BCa).Materials and Methods. This analysis was based on a cohort of 199 BCa patients undergoing RC and bilateral PLND between 2015 and 2022.
The cell death induced by 2-deoxy-D-glucose was found to be due to apoptosis as demonstrated by induction of caspase 3 activity and cleavage of poly (ADP-ribose) polymerase. Breast cancer cells ...
Objective: To assess the diagnostic performance of 18F-fluoro-2-deoxy-d-glucose (18F-FDG) positron emission tomograpy (PET)/computed tomography (CT) in nodal staging before radical cystectomy (RC) and pelvic lymph node dissection (PLND) for bladder cancer (BCa). Materials and methods: This analysis was based on a cohort of 199 BCa patients undergoing RC and bilateral PLND between 2015 and 2022.
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2-Deoxy-d-glucose is a glucose molecule which has the 2-hydroxyl group replaced by hydrogen, so that it cannot undergo further glycolysis. As such; itpositron emission tomography (PET). Chemically, it is 2-deoxy-2-[18F]fluoro-D-glucose, a glucose analog, with the positron-emitting radionuclide fluorine-18serum glucose and insulin during an oral glucose tolerance test of subjects with osteoarthritis". Annals of the Rheumatic Diseases. 66 (2): 260–2. doi:102-deoxyglucose-6-phosphatase (EC 3.1.3.68) catalyzes the reaction 2-deoxy-D-glucose 6-phosphate + H2O ⇌{\displaystyle \rightleftharpoons } 2-deoxy-D-glucoselevels of HVA are measured as a marker of metabolic stress caused by 2-deoxy-D-glucose. HVA presence supports a diagnosis of neuroblastoma and malignantand trisaccharides can be quantified. Glucose uptake in cells of organisms is measured with 2-deoxy-D-glucose or fluorodeoxyglucose. (18F)fluorodeoxyglucosewithin EC number 3.5. The systematic name of this enzyme class is 2-amino-2-deoxy-D-glucose-6-phosphate aminohydrolase (ketol isomerizing). Other names into. Chitobiose is the condensed form of 4‐O‐(2‐amino‐2‐deoxy‐β‐D‐glucopyranosyl)‐2‐amino‐2‐deoxy‐D‐glucose and is an acetylation disaccharide found in2-deoxy-α-D-glucoside + H2O ⇌{\displaystyle \rightleftharpoons } 2-deoxy-D-glucose + an alcohol It belongs to the family of hydrolases, specifically thosespreading such misinformation without evidence. A drug based on 2-deoxy-D-glucose (2-DG) was approved by the Drugs Controller General of India for emergencynumerous studies, either alone or as part of combination therapy. 2-deoxy-D-glucose, or 2DG. 2-Deoxyglucose was the first agent pursued as a possible CRM. ThisN-acetylglucosamine-6-sulfatase, glucosamine (N-acetyl)-6-sulfatase, 2-acetamido-2-deoxy-D-glucose 6-sulfate sulfatase, N-acetylglucosamine 6-sulfate sulfatase, O,N-disulfateTDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose-forming) (EC 5.3.2.4, TDP-4-keto-6-deoxy-D-glucose-3,4-ketoisomeraseATP:N-acetyl-D-glucosamine 6-phosphotransferase. Other names in common use include acetylglucosamine kinase (phosphorylating), ATP:2-acetylamino-2-deoxy-D-glucoseg/mol, exact mass : 164.068473) may refer to: 1,5-Anhydroglucitol 2-Deoxy-D-glucose 5-Deoxyinositol Fucose Fuculose Rhamnose Sorbitan This set index page"Standardized uptake values of normal tissues at PET with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose: variations with body weight and a method for correction"N-acetyl-D-glucosamine (to be precise, 2-(acetylamino)-2-deoxy-D-glucose). These units form covalent β-(1→4)-linkages (like the linkages between glucose unitsDeoxy sugars are sugars that have had a hydroxyl group replaced with a hydrogen atom. Examples include: Deoxyribose, or 2-deoxy-D-ribose, a constituentTDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose-forming) (EC 5.3.2.3, dTDP-6-deoxy-hex-4-ulose isomerasetowards beta-D-galactosyl derivatives of L-mannose, L-lyxose, D-glucose, 2-deoxy-D-glucose, and D-galactose. Nakajima M, Nishimoto M, Kitaoka M (July 2009)more precisely 2-deoxyribose, is a monosaccharide with idealized formula H−(C=O)−(CH2)−(CHOH)3−H. Its name indicates that it is a deoxy sugar, meaningcancer patient prognosis. Moreover, high inducers of ROS such as 2-deoxy-D-glucose and carbohydrate-based inducers of cellular stress induce cancer cell6-dideoxy-alpha-D-glucopyranose transaminase (EC 2.6.1.89, TylB, TDP-3-keto-6-deoxy-D-glucose 3-aminotransferase, TDP-3-dehydro-6-deoxy-D-glucose 3-aminotransferaseCDP-glucose 4,6-dehydratase (EC 4.2.1.45) catalyzes the chemical reaction CDP-glucose ⇌{\displaystyle \rightleftharpoons } CDP-4-dehydro-6-deoxy-D-glucoseL-Rhamnose (6-deoxy-L-mannose) D-Quinovose (6-deoxy-D-glucose), found as part of the sulfolipid sulfoquinovosyl diacylglycerol (SQDG) L-Pneumose (6-deoxy-L-talose)being the first. It is a "linear polysaccharide of β-(1-4)-2-acetamido-2-deoxy-D-glucose". Chitin is highly crystalline and is usually composed of chainsis ATP:D-glucosamine phosphotransferase. Other names in common use include glucosamine kinase (phosphorylating), ATP:2-amino-2-deoxy-D-glucose-6-phosphotransferase "Labeled 2-deoxy-D-glucose analogs. 18F-labeled 2-deoxy-2-fluoro-D-glucose, 2-deoxy-2-fluoro-D-mannose and 14C-2-deoxy-2-fluoro-D-glucose". Journal of2-deoxy-scyllo-Inosose synthase (EC 4.2.3.124, btrC (gene), neoC (gene), kanC (gene)) is an enzyme with systematic name D-glucose-6-phosphate phosphate-lyasewidely accepted somatic mutation theory. Carcinogen Carcinogenesis 2-Deoxy-D-glucose Pyruvic acid Cellular respiration Inverse Warburg effect Warburg O F.; Kandyba, J.; Schmitt, O. (2000). "Use of Fluorine-18 Fluoro-2-deoxy-D-glucose Positron Emission Tomography in Assessing the Process of Tuberculousagents, including SB-204990, 2-deoxy-D-glucose (2DG), 3-bromopyruvate (3-BrPA, bromopyruvic acid, or bromopyruvate), 3-bromo-2-oxopropionate-1-propyl ester1955) is a molecular biologist and a radiation biologist, working on 2-Deoxy-D-glucose therapy in cancer research. His current research interests are experimentalChristoph; Kagan, Avir; Adelman, Neil; Glick, Seymour (1972). "Effect of 2-Deoxy-D-Glucose and Mannoheptulose on the Insulin Response to Amino Acids in Rabbits"UDP-glucose 4,6-dehydratase (EC 4.2.1.76) catalyzes the chemical reaction UDP-glucose ⇌{\displaystyle \rightleftharpoons } UDP-4-dehydro-6-deoxy-D-glucosedehydrogenase, UDP-acetylglucosamine dehydrogenase, UDP-2-acetamido-2-deoxy-D-glucose:NAD oxidoreductase, and UDP-GlcNAc dehydrogenase. This enzymeincluding glucose, galactose and fructose, spontaneously (i.e. non-enzymatically) bond with hemoglobin when present in the bloodstream. However, glucose is onlydTDP-glucose 4,6-dehydratase (EC 4.2.1.46) catalyzes the chemical reaction dTDP-glucose ⇌{\displaystyle \rightleftharpoons } dTDP-4-dehydro-6-deoxy-D-glucosePodocarpus species, Oyvind M. Andersen, Phytochemistry, 1989, Volume 28, Issue 2, Pages 495–497, doi:10.1016/0031-9422(89)80039-1 A novel cytotoxic flavonoid} dTDP-4-dehydro-6-deoxy-L-mannose Hence, this enzyme has one substrate, dTDP-4-dehydro-6-deoxy-D-glucose, and one product, dTDP-4-dehydro-6-deoxy-L-mannoseOn 8 May 2021, DCGI gave permission for emergency use of the drug 2-Deoxy-D-glucose developed by DRDO in collaboration with Dr. Reddy's Laboratories asaldolase and 2-keto-deoxy-6-phosphogluconate (KDPG) aldolase and other common metabolic enzymes to other metabolic pathways to catabolize glucose to pyruvate+ 2-oxoglutarate ⇌{\displaystyle \rightleftharpoons } dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamate Thus, the two substrates of this enzyme are dTDP-4-amino-4galactose and glucose, which form a β-1→4 glycosidic linkage. Its systematic name is β-D-galactopyranosyl-(1→4)-D-glucose. The glucose can be in eitherenzymology, a 2-dehydro-3-deoxygalactonokinase (EC 2.7.1.58) is an enzyme that catalyzes the chemical reaction ATP + 2-dehydro-3-deoxy-D-galactonate ⇌{\displaystylesugar monomer of the aldohexose series of carbohydrates. It is a C-2 epimer of glucose. Mannose is important in human metabolism, especially in the glycosylationMeglumine is a sugar alcohol derived from glucose that contains an amino group modification. It is often used as an excipient in pharmaceuticals and inDeoxyglucose may refer to: 1,5-Anhydroglucitol (1-deoxyglucose) 2-Deoxy-D-glucose (2-deoxyglucose) This set index article lists chemical compounds articlesallows for earlier detection of bony changes. Regarding Fluorine-18 2-deoxy-D-glucose (FDG) positron emission tomography (PET), it is critical to be awareKuhl, D. E. (1978). "Labeled 2-deoxy-D-glucose analogs. 18F-labeled 2-deoxy-2-fluoro-D-glucose, 2-deoxy-2-fluoro-D-mannose and 14C-2-deoxy-2-fluoro-D-glucose"
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