20 results found for: “orexin”.

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Orexin

Orexin (/ɒˈrɛksɪn/), also known as hypocretin, is a neuropeptide that regulates arousal, wakefulness, and appetite. It exists in the forms of orexin-A...

Last Update: 2024-03-20T13:54:42Z Word Count : 6129 Synonim Orexin

Orexin antagonist

An orexin receptor antagonist, or orexin antagonist, is a drug that inhibits the effect of orexin by acting as a receptor antagonist of one (selective...

Last Update: 2023-11-26T18:05:32Z Word Count : 1978 Synonim Orexin antagonist

Orexin receptor

gene (HCRTR1, HCRTR2). Both orexin receptors exhibit a similar pharmacology – the 2 orexin peptides, orexin-A and orexin-B, bind to both receptors and...

Last Update: 2024-01-14T15:41:44Z Word Count : 1052 Synonim Orexin receptor

Narcolepsy

the disorder. Often, those affected have low levels of the neuropeptide orexin, which may be due to an autoimmune disorder triggered in genetically susceptible...

Last Update: 2024-03-19T01:34:27Z Word Count : 7754 Synonim Narcolepsy

Orexin-A

Orexin-A, also known as hypocretin-1, is a naturally occurring neuropeptide and orexin isoform. The orexinergic nucleus in the lateral hypothalamus is...

Last Update: 2023-12-08T05:33:10Z Word Count : 653 Synonim Orexin-A

Lateral hypothalamus

(e.g., anandamide) and the orexin neuropeptides orexin-A and orexin-B are the primary signaling neurochemicals in orexin neurons; pathway-specific neurochemicals...

Last Update: 2023-11-14T13:35:04Z Word Count : 3032 Synonim Lateral hypothalamus

Suvorexant

Suvorexant, sold under the brand name Belsomra, is an orexin antagonist medication which is used in the treatment of insomnia. It is indicated specifically...

Last Update: 2024-02-08T03:36:34Z Word Count : 8958 Synonim Suvorexant

Daridorexant

Daridorexant, sold under the brand name Quviviq, is an orexin antagonist medication which is used for the treatment of insomnia. Daridorexant is taken...

Last Update: 2024-03-12T12:57:49Z Word Count : 4434 Synonim Daridorexant

Hypocretin (orexin) receptor 1

Orexin receptor type 1 (Ox1R or OX1), also known as hypocretin receptor type 1 (HcrtR1), is a protein that in humans is encoded by the HCRTR1 gene. The...

Last Update: 2024-03-10T02:20:49Z Word Count : 1104 Synonim Hypocretin (orexin) receptor 1

Hypocretin (orexin) receptor 2

Orexin receptor type 2 (Ox2R or OX2), also known as hypocretin receptor type 2 (HcrtR2), is a protein that in humans is encoded by the HCRTR2 gene. The...

Last Update: 2024-02-07T01:55:26Z Word Count : 1635 Synonim Hypocretin (orexin) receptor 2

Endocannabinoid system

colocalized on orexin projection neurons in the lateral hypothalamus and many output structures of the orexin system, where the CB1 and orexin receptor 1...

Last Update: 2024-03-28T01:59:36Z Word Count : 7707 Synonim Endocannabinoid system

Lemborexant

Lemborexant, sold under the brand name Dayvigo, is an orexin antagonist medication which is used in the treatment of insomnia. It is indicated specifically...

Last Update: 2024-01-27T04:21:33Z Word Count : 1687 Synonim Lemborexant

Danavorexton

Danavorexton (developmental code name TAK-925) is a selective orexin 2 receptor agonist. It is a small-molecule compound and is administered intravenously...

Last Update: 2024-01-13T11:39:53Z Word Count : 301 Synonim Danavorexton

Wakefulness

and associate with arousal. Orexin deficiency has been identified as responsible for narcolepsy. Research suggests that orexin and histamine neurons play...

Last Update: 2023-12-29T01:31:01Z Word Count : 696 Synonim Wakefulness

Dopaminergic pathways

homodimers, and they also heterodimerized with both orexin receptors. ... In conclusion, orexin receptors have a significant propensity to make homo-...

Last Update: 2024-02-19T18:31:14Z Word Count : 4218 Synonim Dopaminergic pathways

Pediatric narcolepsy

neuronal orexin producing cells located in the lateral hypothalamus and a decrease in orexin concentrations in the cerebral spinal fluid. Normally, orexin acts...

Last Update: 2024-03-19T03:34:26Z Word Count : 2856 Synonim Pediatric narcolepsy

Cataplexy

hypothalamic neurons that produce the neuropeptide hypocretin (also called orexin), which regulates arousal and has a role in stabilization of the transition...

Last Update: 2024-02-19T14:52:02Z Word Count : 2466 Synonim Cataplexy

Seltorexant

an orexin antagonist medication which is under development for the treatment of depression and insomnia. It is a selective antagonist of the orexin OX2...

Last Update: 2024-01-07T07:20:28Z Word Count : 498 Synonim Seltorexant

Catabolism

least some catabolic effects have been discovered, including cytokines, orexin (known as hypocretin), and melatonin.[citation needed] The word catabolism...

Last Update: 2023-12-24T19:44:23Z Word Count : 453 Synonim Catabolism

Postprandial somnolence

sensed by glucose-inhibited neurons in the lateral hypothalamus. These orexin-expressing neurons appear to be hyperpolarised (inhibited) by a glucose-activated...

Last Update: 2024-03-21T16:33:42Z Word Count : 1778 Synonim Postprandial somnolence

Main result

Orexin

Orexin (), also known as hypocretin, is a neuropeptide that regulates arousal, wakefulness, and appetite. It exists in the forms of orexin-A and orexin-B. The most common form of narcolepsy, type 1, in which the individual experiences brief losses of muscle tone ("drop attacks" or cataplexy), is caused by a lack of orexin in the brain due to destruction of the cells that produce it.There are 50,000–80,000 orexin-producing neurons in the human brain, located predominantly in the perifornical area and lateral hypothalamus. They project widely throughout the central nervous system, regulating wakefulness, feeding, and other behaviours. There are two types of orexin peptide and two types of orexin receptor.Orexin was discovered in 1998 almost simultaneously by two independent groups of researchers working on the rat brain. One group named it orexin, from orexis, meaning "appetite" in Greek; the other group named it hypocretin, because it is produced in the hypothalamus and bears a weak resemblance to secretin, another peptide. Officially, hypocretin (HCRT) is used to refer to the genes and transcripts, while orexin is used to refer to the encoded peptides. There is considerable similarity between the orexin system in the rat brain and that in the human brain.


orexin
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