20 results found for: “neprilysin”.

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Neprilysin

Neprilysin (/ˌnɛprɪˈlaɪsɪn/), also known as membrane metallo-endopeptidase (MME), neutral endopeptidase (NEP), cluster of differentiation 10 (CD10), and...

Last Update: 2023-12-03T18:39:39Z Word Count : 2697 Synonim Neprilysin

Sacubitril/valsartan

fixed-dose combination medication for use in heart failure. It consists of the neprilysin inhibitor sacubitril and the angiotensin receptor blocker valsartan. The...

Last Update: 2024-02-27T06:36:26Z Word Count : 3390 Synonim Sacubitril/valsartan

Sacubitril

(LBQ657) by de-ethylation via esterases. Sacubitrilat inhibits the enzyme neprilysin, which is responsible for the degradation of atrial and brain natriuretic...

Last Update: 2024-03-25T15:48:06Z Word Count : 526 Synonim Sacubitril

MME

Engineering (MME) Membrane metallo-endopeptidase, an enzyme also named neprilysin Michigan Merit Exam, a minimum-competency test for students Mitsubishi...

Last Update: 2024-03-18T05:44:16Z Word Count : 244 Synonim MME

Endopeptidase

at pH 2. Glutamyl endopeptidase - cuts after Glu. Works best at pH 8. Neprilysin "endopeptidase". Merriam-Webster. Archived from the original on 21 December...

Last Update: 2023-12-18T19:03:33Z Word Count : 226 Synonim Endopeptidase

Drug-induced angioedema

(ACE) inhibitors, angiotensin II antagonists (ARBs), and Angiotensin-Neprilysin Inhibitor LCZ969.: 120  The angioedema appears to be dose dependent as...

Last Update: 2023-10-31T05:50:34Z Word Count : 287 Synonim Drug-induced angioedema

Brain natriuretic peptide 32

nesiritide in patients with acute decompensated heart failure. Blockade of neprilysin, a protease known to degrade members of the natriuretic peptide family...

Last Update: 2024-03-28T02:33:27Z Word Count : 4307 Synonim Brain natriuretic peptide 32

Bradykinin

different kininases: angiotensin-converting enzyme (ACE, kininase II), neprilysin, NEP2, aminopeptidase P (APP), carboxypeptidase N (CPN, kininase I), Carboxypeptidase...

Last Update: 2024-02-26T07:54:31Z Word Count : 2006 Synonim Bradykinin

Omapatrilat

experimental antihypertensive agent that was never marketed. It inhibits both neprilysin (neutral endopeptidase, NEP) and angiotensin-converting enzyme (ACE)....

Last Update: 2023-01-22T23:42:34Z Word Count : 231 Synonim Omapatrilat

Natriuretic peptide

Natriuretic peptides will lose their activity when degraded by the enzyme neprilysin which is found on the plasma membrane. The existence of natriuretic peptides...

Last Update: 2023-12-03T07:08:37Z Word Count : 1731 Synonim Natriuretic peptide

Kell antigen system

protein contains sequence and structural similarity to members of the neprilysin (M13) family of zinc endopeptidases. There are several alleles of the...

Last Update: 2022-10-18T20:50:52Z Word Count : 1311 Synonim Kell antigen system

Collagenase

valine or threonine and forms part of the S1' subsite in thermolysin and neprilysin, 'b' is an uncharged residue, and 'c' a hydrophobic residue. Proline is...

Last Update: 2023-12-21T10:27:12Z Word Count : 758 Synonim Collagenase

Angiotensin (1-7)

The polypeptide Ang I can be converted into Ang (1-7) by the actions of neprilysin (NEP) and thimet oligopeptidase (TOP) enzymes. Also, Ang II can be hydrolyzed...

Last Update: 2024-01-01T00:58:10Z Word Count : 764 Synonim Angiotensin (1-7)

Valsartan

Gong J, Lefkowitz MP, Rizkala AR, et al. (September 2014). "Angiotensin-neprilysin inhibition versus enalapril in heart failure". The New England Journal...

Last Update: 2024-02-09T22:09:49Z Word Count : 3441 Synonim Valsartan

Atrial natriuretic peptide

urodilatin, and adrenomedullin. Neutral endopeptidase (NEP) also known as neprilysin is the enzyme that metabolizes natriuretic peptides. Several inhibitors...

Last Update: 2024-03-24T00:31:39Z Word Count : 3832 Synonim Atrial natriuretic peptide

Cardiology

fibrillation instead of warfarin PARADIGM-HF (2014) — use of angiotensin-neprilysin inhibitor in heart failure ISCHEMIA (2020) — medical therapy is as good...

Last Update: 2024-03-25T15:21:41Z Word Count : 9064 Synonim Cardiology

Heart failure

inhibitors, angiotensin receptor blockers, or angiotensin receptor-neprilysin inhibitors, along with beta blockers, mineralocorticoid receptor antagonists...

Last Update: 2024-03-15T10:02:00Z Word Count : 15476 Synonim Heart failure

NEP

Petersburg, Russia, est. 1988 Nepal, FIFA and IOC code NEP Nepr, a Norse god Neprilysin, or neutral endopeptidase Needle exchange programme Net ecosystem production...

Last Update: 2023-11-01T03:03:17Z Word Count : 171 Synonim NEP

Cerebral amyloid angiopathy

endocytosis by astrocytes and microglial cells, (2) enzymatic degradation by neprilysin or insulysin (3) cleared by way of the blood–brain barrier or (4) drained...

Last Update: 2024-01-13T12:08:50Z Word Count : 1768 Synonim Cerebral amyloid angiopathy

Metalloproteinase

valine or threonine and forms part of the S1' subsite in thermolysin and neprilysin, 'b' is an uncharged residue, and 'c' a hydrophobic residue. Proline is...

Last Update: 2024-01-25T21:10:34Z Word Count : 751 Synonim Metalloproteinase

Main result

Neprilysin

Neprilysin (), also known as membrane metallo-endopeptidase (MME), neutral endopeptidase (NEP), cluster of differentiation 10 (CD10), and common acute lymphoblastic leukemia antigen (CALLA) is an enzyme that in humans is encoded by the MME gene. Neprilysin is a zinc-dependent metalloprotease that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. It also degrades the amyloid beta peptide whose abnormal folding and aggregation in neural tissue has been implicated as a cause of Alzheimer's disease. Synthesized as a membrane-bound protein, the neprilysin ectodomain is released into the extracellular domain after it has been transported from the Golgi apparatus to the cell surface. Neprilysin is expressed in a wide variety of tissues and is particularly abundant in kidney. It is also a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL.Hematopoietic progenitors expressing CD10 are considered "common lymphoid progenitors", which means they can differentiate into T, B or natural killer cells. CD10 is of use in hematological diagnosis since it is expressed by early B, pro-B and pre-B lymphocytes, and by lymph node germinal centers. Hematologic diseases in which it is positive include ALL, angioimmunoblastic T cell lymphoma, Burkitt lymphoma, chronic myelogenous leukemia in blast crisis (90%), diffuse large B-cell lymphoma (variable), follicular center cells (70%), hairy cell leukemia (10%), and myeloma (some). It tends to be negative in acute myeloid leukemia, chronic lymphocytic leukemia, mantle cell lymphoma, and marginal zone lymphoma. CD10 is found on non-T ALL cells, which derive from pre-B lymphocytes, and in germinal center-related non-Hodgkin lymphoma such as Burkitt lymphoma and follicular lymphoma, but not on leukemia cells or lymphomas, which originate in more mature B cells.


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