20 results found for: “hexokinase”.

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Hexokinase

A hexokinase is an enzyme that phosphorylates hexoses (six-carbon sugars), forming hexose phosphate. In most organisms, glucose is the most important substrate...

Last Update: 2021-05-09T08:52:44Z Word Count : 1363 Synonim Hexokinase

Hexokinase deficiency

Hexokinase deficiency is an anemia-causing condition associated with inadequate hexokinase. Specifically, the HK1 isozyme is involved. An acronym for hexokinase...

Last Update: 2021-02-28T11:39:08Z Word Count : 165 Synonim Hexokinase deficiency

Glycolysis

impervious to G6P, hexokinase essentially acts to transport glucose into the cells from which it can then no longer escape. Hexokinase is inhibited by high...

Last Update: 2021-05-01T00:54:05Z Word Count : 8279 Synonim Glycolysis

HK1

Hexokinase-1 (HK1) is an enzyme that in humans is encoded by the HK1 gene on chromosome 10. Hexokinases phosphorylate glucose to produce glucose-6-phosphate...

Last Update: 2020-12-08T00:26:03Z Word Count : 2960 Synonim HK1

Enzyme activator

enzyme's other subunits, and thus the substrate acts as an activator. Hexokinase-I (HK-I) is an enzyme activator because it draws glucose into the glycolysis...

Last Update: 2021-01-28T05:18:01Z Word Count : 574 Synonim Enzyme activator

Phosphorylation

specific glucokinase (ATP-D-glucose 6-phosphotransferase) and non-specific hexokinase (ATP-D-hexose 6-phosphotransferase). Hepatic cells are freely permeable...

Last Update: 2021-02-27T21:58:39Z Word Count : 1763 Synonim Phosphorylation

Glucokinase

hypoglycemia. Glucokinase (GK) is a hexokinase isozyme, related homologously to at least three other hexokinases. All of the hexokinases can mediate phosphorylation...

Last Update: 2021-04-09T01:21:05Z Word Count : 5513 Synonim Glucokinase

2-Deoxy-D-glucose

marker for tissue glucose uptake and hexokinase activity. Many cancers have elevated glucose uptake and hexokinase levels. 2-Deoxyglucose labeled with...

Last Update: 2021-05-12T00:08:08Z Word Count : 1670 Synonim 2-Deoxy-D-glucose

HK3

Hexokinase 3 also known as HK3 is an enzyme which in humans is encoded by the HK3 gene on chromosome 5. Hexokinases phosphorylate glucose to produce glucose-6-phosphate...

Last Update: 2021-04-03T14:36:49Z Word Count : 1860 Synonim HK3

Enzyme assay

reaction. For example, figure 1 shows the coupled assay for the enzyme hexokinase, which can be assayed by coupling its production of glucose-6-phosphate...

Last Update: 2021-01-24T19:15:00Z Word Count : 2953 Synonim Enzyme assay

HK2

Hexokinase 2 also known as HK2 is an enzyme which in humans is encoded by the HK2 gene on chromosome 2. Hexokinases phosphorylate glucose to produce glucose-6-phosphate...

Last Update: 2021-04-03T14:36:44Z Word Count : 2498 Synonim HK2

Protein

The enzyme hexokinase is shown as a conventional ball-and-stick molecular model. To scale in the top right-hand corner are two of its substrates, ATP and...

Last Update: 2021-05-12T19:05:16Z Word Count : 9484 Synonim Protein

Tumor hypoxia

for glycolysis to proceed, the hexokinase reaction activates glucose for subsequent steps. In hypoxic tumors, hexokinase mRNA abundance is significantly...

Last Update: 2021-04-22T16:14:19Z Word Count : 5424 Synonim Tumor hypoxia

Glucose 6-phosphate

phosphorylation of glucose on the sixth carbon. This is catalyzed by the enzyme hexokinase in most cells, and, in higher animals, glucokinase in certain cells, most...

Last Update: 2021-02-20T09:14:36Z Word Count : 884 Synonim Glucose 6-phosphate

Polyol pathway

phosphorylation from the enzyme hexokinase. However, if large amounts of glucose are present (as in diabetes mellitus), hexokinase becomes saturated and the...

Last Update: 2020-04-11T18:01:15Z Word Count : 809 Synonim Polyol pathway

Insulin

(G-6-P) by glucokinase (hexokinase IV) which is not inhibited by G-6-P in the way that the hexokinases in other tissues (hexokinase I – III) are affected...

Last Update: 2021-05-05T20:05:34Z Word Count : 13423 Synonim Insulin

Binding site

the transferase hexokinase catalyzes the phosphorylation of glucose to make glucose-6-phosphate. Active site residues of hexokinase allow for stabilization...

Last Update: 2021-05-13T10:55:48Z Word Count : 3037 Synonim Binding site

TP53-inducible glycolysis and apoptosis regulator

TIGAR acts as a direct regulator of fructose-2,6-bisphosphate levels and hexokinase 2 activity, and this can lead indirectly to many changes within the cell...

Last Update: 2021-03-20T01:16:18Z Word Count : 3425 Synonim TP53-inducible glycolysis and apoptosis regulator

Blood sugar level

of error. The two most common employed enzymes are glucose oxidase and hexokinase. Average blood glucose concentrations can also be measured. This method...

Last Update: 2021-05-07T07:10:21Z Word Count : 3567 Synonim Blood sugar level

Chemical specificity

isozyme of Hexokinase. Its absolute specificity refers to glucose being the only hexose that is able to be its substrate, as opposed to hexokinase, which...

Last Update: 2021-03-08T12:28:06Z Word Count : 1631 Synonim Chemical specificity

Main result

Hexokinase

A hexokinase is an enzyme that phosphorylates hexoses (six-carbon sugars), forming hexose phosphate. In most organisms, glucose is the most important substrate for hexokinases, and glucose-6-phosphate is the most important product. Hexokinase possesses the ability to transfer an inorganic phosphate group from ATP to a substrate. Hexokinases should not be confused with glucokinase, which is a specific isoform of hexokinase. All hexokinases are capable of phosphorylating several hexoses but glucokinase acts with a 50-fold lower substrate affinity and its main hexose substrate is glucose.


hexokinase
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