Telomeric repeat–containing RNA


Telomeric repeat-containing RNA (TERRA) is a long non-coding RNA transcribed from telomeres - repetitive nucleotide regions found on the ends of chromosomes that function to protect DNA from deterioration or fusion with neighboring chromosomes.

Telomeric Repeat-Containing RNA TERRA: A Noncoding RNA Connecting Telomere Biology to Genome Integrity Telomeres are dynamic nucleoprotein structures that protect the ends of chromosomes from degradation and activation of DNA damage response. For this reason, telomeres are essential to genome integrity.

Telomeric repeat-containing RNA (TERRA) has been identified as a telomere-associated regulator of chromosome end protection. Here, we report that TERRA can also be found in extracellular fractions that stimulate innate immune signaling.

Telomeric repeat-containing RNA (referred to as TERRA), a noncoding RNA molecule, has recently been found in mammalian cells. The detailed structural features and function of the TERRA RNA at human chromosome ends remain unclear, although this RNA molecule may be a key component of the telomere machinery.

Telomeric repeat-containing RNA (TERRA) has been identified as a telomere-associated regulator of chromosome end protection. Here, we report that TERRA can also be found in extracellular fractions that stimulate innate immune signaling. We identified extracellular forms of TERRA in mouse tumor and

Until now, telomeres have been considered to be transcriptionally silent. We demonstrate that mammalian telomeres are transcribed into telomeric repeat-containing RNA (TERRA). TERRA molecules are...

A recent analysis has identified telomeric repeat‐containing RNA (TERRA), a large non‐coding RNA in animals and fungi, which forms an integral component of telomeric heterochromatin. TERRA transcription occurs at most or all chromosome ends and it is regulated by RNA surveillance factors and in response to changes in telomere length.

Telomeric repeat containing RNAs (TERRA) are small RNA molecules synthesized from telomeric regions which were previously considered as silent genomic domains. In normal cells, these RNAs are...

DOI: 10.1126/SCIENCE.1147182 Corpus ID: 20693275. Telomeric Repeat-Containing RNA and RNA Surveillance Factors at Mammalian Chromosome Ends @article{Azzalin2007TelomericRR, title={Telomeric Repeat-Containing RNA and RNA Surveillance Factors at Mammalian Chromosome Ends}, author={C. Azzalin and P. Reichenbach and L. Khoriauli and E. Giulotto and J. Lingner}, journal={Science}, year={2007 ...

Telomeric repeat-containing RNA TERRA: a noncoding RNA connecting telomere biology to genome integrity. Author: Cusanelli E1, Chartrand P2. Affiliation: 1Max F. Perutz Laboratories, Department of Chromosome Biology, University of Vienna Vienna, Austria. 2Department of Biochemistry and Molecular Medicine, Université de Montréal Montréal, QC ...

Despite their heterochromatic state, telomeres are transcribed giving rise to long noncoding RNAs (lncRNA) called TERRA (telomeric repeat-containing RNA). TERRA molecules play critical roles in telomere biology, including regulation of telomerase activity and heterochromatin formation at chromosome ends.

Telomeric repeat containing RNAs (TERRA) are small RNA molecules synthesized from telomeric regions which were previously considered as silent genomic domains. In normal cells, these RNAs are transcribed in a direction from subtelomeric region towards the chromosome ends, but in case of cancer cells, their expression remains limited or absent.

Telomeric repeat-containing RNA (TERRA) has been identified as a telomere-associated regulator of chromosome end protection. Here, we report that TERRA can also be found in extracellular fractions that stimulate innate immune signaling.

Telomeric repeat-containing RNA (referred to as TERRA), a noncoding RNA molecule, has recently been found in mammalian cells. The detailed structural features and function of the TERRA RNA at human chromosome ends remain unclear, although this RNA molecule may be a key component of the telomere machinery.

Role of telomeric repeat-containing RNA in telomeric chromatin remodeling during the early expansion of human embryonic stem cells Sicong Zeng,*,†,1 Lvjun Liu,*,†,1 Yi Sun,*,† Guangxiu Lu,† and Ge Lin*,†,2 *Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha, China ...

Telomeric repeat-containing RNA (TERRA) has been identified as a telomere-associated regulator of chromosome end protection. Here, researchers from the Wistar Institute report that TERRA can also be found in extracellular fractions that stimulate innate immune signaling. They identified extracellular forms of TERRA in mouse tumor and embryonic brain tissue, as well as in human tissue ...

Sarcopenia is defined as aging-related loss of muscle mass and function. Telomere length in chromosomes shortens with age and is modulated by telomeric repeat-containing RNA (TERRA).

Here, we report that telomeric repeat-containing RNA (TERRA) induces a genome-wide alteration of gene expression in telomere-elongated cancer cells. Using three different cell lines, we found that telomere elongation up-regulates TERRA signal and down-regulates innate immune genes such as STAT1, ISG15 and OAS3 in vivo.

The telomere repeats containing RNA (TERRA) is transcribed from the C-rich strand of telomere DNA and comprises of UUAGGG nucleotides repeats in humans. The TERRA RNA repeats can exist in single stranded, RNA-DNA hybrid and G-quadruplex forms in the cell.

Taken together, these results highlight the role of TERRA in hESC telomere elongation and homeostasis in the acquisition and/or maintenance of stem cell pluripotency.—Zeng, S., Liu, L., Sun, Y., Lu, G., Lin, G. Role of telomeric repeat-containing RNA in telomeric chromatin remodeling during the early expansion of human embryonic stem cells.

Telomeric Repeat-Containing RNA and RNA Surveillance Factors at Mammalian Chromosome Ends Claus M. Azzalin, 1,2,3Patrick Reichenbach, Lela Khoriauli,4 Elena Giulotto,4 Joachim Lingner1,2,3* Telomeres, the DNA-protein complexes located at the end of linear eukaryotic chromosomes, are essential for chromosome stability.

Telomeres are transcribed into long, noncoding telomeric repeat-containing RNAs (TERRA) that have been implicated in the regulation of telomerase, the enzyme that lengthens telomeres, in heterochromatin formation at telomeres, and in telomere stability. This study aimed to evaluate the correlation between TERRA expression and long-term oncologic outcomes in colorectal cancer (CRC).

Telomeric repeat-containing RNA (referred to as TERRA), a noncoding RNA molecule, has recently been found in mammalian cells. The detailed structural features and function of the TERRA RNA at human chromosome ends remain unclear, although this RNA molecule may be a key component of the telomere machinery.

A recent analysis has identified telomeric repeat-containing RNA (TERRA), a large non-coding RNA in animals and fungi, which forms an integral component of telomeric heterochromatin.

More than 25 years ago, the discovery of a transcriptional activity at telomeres of protozoa ended the long‐lasting belief that telomeres were transcriptionally silent. Since then, progressively accumulating evidences established that production of TElomeric Repeat‐containing RNA (TERRA) was a general feature of eukaryotic cells.

Telomeres play crucial roles in the maintenance of genome integrity and control of cellular senescence. Most eukaryotic telomeres can be transcribed to generate a telomeric repeat-containing RNA (TERRA) that persists as a heterogeneous nuclear RNA and can be developmentally regulated. However, the precise function and regulation of TERRA in normal and cancer cell development remains poorly ...

Indeed, from yeast to humans, telomeres are found to be transcribed into TElomeric Repeat-containing RNA (TERRA), transcripts with emerging roles in telomere maintenance and genome stability (Bettin et al., 2019; Cusanelli et al., 2013).

Yet, telomeric DNA sequences are transcribed into long non-coding RNAs named TElomere Repeat-containing RNA (TERRA). As TERRA molecules mostly localize at telomeres, major research efforts have been made to understand their functions, and how TERRA transcription is regulated and affects telomere structure.

Telomeric repeat-containing RNA, an lncRNA transcribed from the subtelomeric sequences, is characterized by telomeric repeats of UUAGGG at its 3′-end. Telomeric repeat-containing RNA is in-volved in the maintenance and regulation of telomere homeo-stasis by inhibiting telomerase activity and altering the length of

2020年8月29日 Telomeres are transcribed into long non-coding RNAs known as Telomeric Repeat-Containing RNA (TERRA). 00:35:58. 00:35:56. 00:36: Azzalin • Cytowane przez 1178Luke • Cytowane przez 266Cusanelli • Cytowane przez 140Informacje o�fragmentach z�odpowiedzią14 kwi 2015 � 14 kwi 2015 � 2 wrz 2009 � 2 lis 2015 � 22 lis 2019 � 13 wrz 2019 � 14 gru 2017 � 30 paź 2020 � 5 lip 2018 � 1 maj 2014 � 2 lis 2007 � . Telomeric repeat-containing RNA (TERRA) is a long non-coding RNA transcribed from telomeres - repetitive nucleotide regions found on the ends of 14 Apr 2015 Despite their heterochromatic state, telomeres are transcribed giving rise to long noncoding RNAs (lncRNA) called TERRA (telomeric repeat- 2 Sep 2009 Telomeres, the physical ends of eukaryotic chromosomes, consist of tandem arrays of short DNA repeats and a large set of specialized proteins 14 Apr 2015 Telomeric repeat-containing RNA TERRA: a noncoding RNA connecting telomere biology to genome integrity. They have been shown to be 22 Mar 2018 Nevertheless, telomeric DNA is actively transcribed, leading to the synthesis of telomeric repeat-containing noncoding RNA or TERRA. telomere synthesis, inactivating the X chromosome and transporting proteins to SARS is severe acute respiratory syndrome and it contains RNA genes&nbThe only difference is that in RNA, all of the T nucleotides are replaced with U nucleotides; during RNA synthesis, U is incorporated when there is an A in the 21 Jan 2021 They interact with tRNAs and other molecules that are crucial to protein synthesis. Here we mutate an invertebrate orphan relaxin receptor gene, the Drosophila Leucine-rich repeat-containing G protein-coupled receptor 3 (Lgr3), and find body 25 Sep 2018 Ribosomal RNA (rRNA) is one of the main components of ribosomes. 06 We should be able to get the same result that we got with the stimulation. Here, we 1 May 2014 Telomeric DNA consists of TTAGGG tandem repeats associated with an array of telomere binding proteins that constitute the shelterin complex [1, 2 Nov 2007 We demonstrate that mammalian telomeres are transcribed into telomeric repeat–containing RNA (TERRA). In bacteria, the small and large rRNAs contain about 1500 and 00:35:53. 24 In fact, that's true. A recent analysis has identified telomeric repeat-containing RNA (TERRA), a large non-coding RNA in animals and fungi, which forms an integral component of 2 Nov 2015 Telomeric repeat-containing RNA (TERRA) has been identified as a telomere-associated regulator of chromosome end protection. TERRA molecules are 30 Oct 2020 Telomeric repeat-containing RNA (TERRA) molecules play important roles at telomeres, from heterochromatin regulation to telomerase activity Publication PAR-TERRA is the main contributor to telomeric repeat-containing RNA transcripts in normal and cancer mouse cells Telomeres are transcribed into long, noncoding telomeric repeat-containing RNAs (TERRA) that have be. TERRA molecules are heterogeneous in length, are 17 Aug 2016 They are transcribed by RNA polymerase II, giving rise to transcripts that contain UUAGGG-repeats, being the presence of this repeat their main 10 Jul 2012 (3) Telomeres are transcribed into telomeric repeat-containing RNA (TERRA)(4, 5) consisting of tandem UUAGGG repeats with variable 19 Jul 2008 Very recently, a breaking finding from two groups demonstrated that telomere DNA is transcribed into telomeric repeat-containing RNA in  RNA constructions of up to 25 GGGUUA repeats form higher order structures towards chromosome ends into telomeric repeat-containing RNA (TERRA). Emilio Cusanelli1* and Pascal 16 Jul 2019 Most normal human somatic cells express only very low levels of telomerase and telomeres shorten with continuous cell division cycles. 18 The RNAs all come back. 1 Sep 2017 Telomeric repeat-containing RNA (TERRA) is activated during early mouse development, from 2-cell to blastocyst stages, in a cell We demonstrate that mammalian telomeres are transcribed into telomeric repeat-containing RNA (TERRA)

About Telomeric repeat–containing RNA

About

Digital Compliance Disclosure


We and our partners use technology such as cookies and localStorage on our site to personalise content and ads, provide social media features, and analyse our traffic. Click to consent to the use of this technology across the web or click Privacy Policy to review details about our partners and your privacy settings.
Category

Recently

Newly