The mitomycins are a family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae. They include mitomycin A, mitomycin B, and mitomycin C. When the name mitomycin occurs alone, it usually refers to mitomycin C...
Mitomycin C is a mitomycin that is used as a chemotherapeutic agent by virtue of its antitumour activity. It is given intravenously to treat upper gastro-intestinal cancers (e.g. esophageal carcinoma), anal cancers, and breast cancers...
The mitomycins are a family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.[1][2] They include mitomycin A, mitomycin B...
Митомицин (mitomycin) 40 мг №1 Zydus - Инструкция, Цена и описание, заказ и доставка. Полная информация по препарату.
Mitomycin is used in palliative tumour therapy. Mitomycin is administered intravenously as monochemotherapy or in combined cytostatic chemotherapy in the case of
Medscape - Indication-specific dosing for (mitomycin), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.
Mitomycin official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions and pharmacology.
Веро-Митомицин vero-mitomycin mitomycin антибиотик с противоопухолевой активностью Веро-Митомицин (Vero-mitomycin). Форма выпуска, состав и упаковка.
Physician reviewed mitomycin patient information - includes mitomycin description, dosage and directions.
Mitomycin ( 28.1.110 ) is an antineoplastic antibiotic against a wide variety of cancer types produced by Streptomyces Mitomycin serve as promising scaffolds for small molecule anticancer drugs.
Mitomycin (Mutamycin) chemotherapy side effects, how it's given, how it works, precautions and self care tips for treatment of adenocarcinoma of the stomach or pancreas.
Mitomycin C is an antibiotic which acts as a double-stranded DNA alkylating agent. It covalently crosslinks DNA, inhibiting DNA synthesis and cell proliferation.
Mitomycin C can inhibit RNA and protein synthesis at high concentrations. Mitomycin-C (MMC) is an alkylating antibiotic substance with antiproliferative and antifibrotic actions.
mitomycin — noun Any of a family of aziridine containing natural products isolated from the filamentous bacterium Streptomyces lavendulae, one of which is used as a chemotherapeutic agent …
Journal of the American Chemical Society ( IF 15. The mitomycins are a group of highly potent antibiotics, produced by the microorganism Streptomyces caespitosus, as discovered in Japan in the 1950s [1. ProduktyGenyDokumentyDokumentacja technicznaZawartość witryny. Download Prime PubMed App to iPhone, iPad, or Android. Name: Mitomycins; Accession Number: DBCAT000710; Description. [隋毅]. ), metabolites of microorganisms (gliotoxins, 10 sie 2021 3 shows represen- tative chemical structures of ansamycins and mitomycins derived from AHBA. Mytomycin represented by general formula: Wherein X is amino, substituted amino, hydroxyl or alkoxy; Syntheses of 1,2,3,4,5,6-Hexahydro-2,3-benzazocin-5-ones as Possible Intermediates in the Biosynthesis of Mitomycins. University of Hong Kong, Pokfulam Mitomycins A and B were isolated in 1956, followed by Mitomycin C in 1958. Drug type: Mitomycin is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. Studies towards enantioselective synthesis of mitomycins A and B series. Shortly after the isolation of the mitomycins, their significant antitumor properties were discovered. ETD Collection for Fordham University. (2017). Download scientific diagram | Reduction/oxidation pathways of the mitomycins. Their structures were elucidated 7-N-(mercaptoalkyl)mitomycins: implications of cyclization for drug function. • Mapping the structures engaged the interests of chemists and crystallographers 8 mar 2002 New naturally occurring mitomycins and related novel compounds were isolated from a fermentation broth. The mitomycins are a group of antitumor antibiotics that covalently bind to DNA after reductive activation. AAI7425125. The following 38 files are in this category, out of 38 total. the derivation of mitomycin G 2 from mitomycin B 5 via mitomycin H. Mitomycin C inhibits fibroblast function by a dose- Mitomycins, a family of potent antitumor antibiotics that induce DNA alkylations, require prior activation generating a reactive electrophile responsible for Mitomycins and porfiromycin, generally nonreactive in the natural oxidized state, behave as bifunctional "alkylating" agents upon chemical or enzymatic Słowo kluczowe:'mitomycins'. This medication is classified as an "antitumor antibiotic. (redirected from Mitomycins) Also found in: Thesaurus, Medical, Encyclopedia, Wikipedia. mitomycin. MMC began use in clinical cancer chemotherapy in the Mitomycins refer to a group of aziridine-containing natural products which are obtained from either Streptomyces caespitosus or Streptomyces lavendulae. SIUTA, GERALD J, "STUDIES DIRECTED TOWARD A TOTAL SYNTHESIS OF THE MITOMYCINS. " (For 30 cze 2018 Media in category "Mitomycins". Filter & Sort. ), polyether antibiotics (lasalocid A, monensin, etc. The mitomycins are a family of aziridine containing natural products. 419 ) Pub Date : 2002 May 1New mitomycins and processes for production thereof. A group of methylazirinopyrroloindolediones obtained from certain Streptomyces strains. from publication: Mitomycin resistance in mammalian cells expressing the PubMed journal article: Isolation of new fractions of antitumor mitomycins. (Thesis). The mitomycins are a family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae. 21 cze 2018 Sui, Y. The mitomycins and porfiromycins form a group of closely related bactericidal and cytotoxic antibiotics produced by several Streptomyces species. 3 cze 2016 The mitomycins are a family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae. . Przepraszamy, wystąpił nieoczekiwany błąd Mitomycins and porfiromycin, generally nonreactive in the natural oxidized state, behave as bifunctional "alkylating" agents upon chemical or enzymatic The Structures of Mitomycins A, B and C and Porfiromycin--Part I as a key intermediate in the biosynthesis of antitumor antibiotic mitomycins. Previous antitumor antibiotics (halichondrins, mitomycins, etc. 10. The Biosynthetic Clusters for Rifamycin and 12 sie 2021 AHBA is the precursor for synthesizing the mC7N units, the characteristic structural component of ansamycins and mitomycins antibiotics, These novel mitomycins have exo-methylene double bond at the 9th and 10th positions. mi·to·my The mitomycins are a family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae. " (1974). Dosage Forms & Strengths · Stomach Cancer, Pancreas Cancer · Anal Carcinoma (Off-label) · Dosage Modification · Renal Impairment · Monitor · Dosing Considerations. BACKGROUND: The mitomycins are natural products that contain a variety of functional groups, including aminobenzoquinone- and aziridine-ring systems. Mitomycin C is a chemotherapeutic agent because of Quantity:
The mitomycins are a family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae. They include mitomycinMitomycin C is a mitomycin that is used as a chemotherapeutic agent by virtue of its antitumour activity It is given intravenously to treat upper gastro-intestinalderived from the mitomycins by reduction and are the active alkylating agents responsible for the antitumor activity of the mitomycins. Maliepaard, Marc;anthracyclines include: Actinomycin-D Bleomycin Mitomycin-C Mitoxantrone Phototrexate Antimetabolites, particularly mitomycin C (MMC), are commonly used in AmericaMitobronitol Pipobroman Triazenes (Dacarbazine# Mitozolomide§ Temozolomide) Intercalation Streptomyces (Dactinomycin# Bleomycin# Mitomycins Plicamycin)(acyclovir) Certain chemotherapy medications such as gemcitabine and mitomycin C Quinine Oxymorphone Quetiapine Bevacizumab Sunitinib Platelet aggregationCompetence in S. pneumoniae is induced by DNA-damaging agents such as mitomycin C, fluoroquinolone antibiotics (norfloxacin, levofloxacin and moxifloxacin)protocol is the preoperative use of chemotherapy with 5-fluorouracil and mitomycin and medical radiation for squamous cell carcinomas of the anal canal.vitiligo. Mitomycin C (MMC) is from a class of antibiotics that are used broadly in chemotherapy, often with gastrointestinal related cancers. Mitomycin C caneffectiveness altogether. Traditionally, chemotherapeutic adjuvants, such as mitomycin C (MMC) or 5-fluorouracil (5-FU), are applied with soaked sponges on thenerve growth factor (NGF) in combination with docosahexaenoic acid (DHA). Mitomycin C worsens post-surgical dry eye. PRK may be performed on one eye at aStreptomyces caespitosus is a species of actinobacteria. It produces chemotherapeutic drug mitomycin C. "Streptomyces caespitosus". v t ekidney transplantations. Other cytotoxic antibiotics are anthracyclines, mitomycin C, bleomycin, mithramycin. Antibodies are sometimes used as a quick andlicense number Gliolan (EU/1/07/413/001-003)] license number: Mitomycin 2 (394.00.00) und Mitomycin medac (394.01.00) [EUROPÄISCHE PATENTANMELDUNG ] at http://wwwof time. The chemotherapeutic agents generally infused during IPHC are mitomycin-C and cisplatin. IPHC is generally used after surgical removal of as muchcapsule and the wound bed is treated for several seconds to minutes with mitomycin C (MMC, 0.5–0.2 mg/ml) or 5-fluorouracil (5-FU, 50 mg/ml) soaked spongesinstance, Claverys et al. in 2006 showed that the DNA damaging agents mitomycin C (a DNA cross-linking agent) and fluoroquinolone (a topoisomerase inhibitorthe anthracyclines and the bleomycins; other prominent examples include mitomycin C and actinomycin. Among the anthracyclines, doxorubicin and daunorubicinmolecular formula C 2H 4NH. Several drugs feature aziridine rings, including mitomycin C, porfiromycin, and azinomycin B (carzinophilin). The bond angles inMigrating motor complex, a cleaning reflex of the gastrointestinal tract Mitomycin C, a DNA crosslinker used in cancer treatment as an anti-tumour antibioticthese organisms to the DNA damaging agents UV irradiation, bleomycin or mitomycin C induces species-specific cellular aggregation. UV-induced cellular aggregationtransformation is induced in Streptococcus pneumoniae by the DNA damaging agents mitomycin C (a DNA cross-linking agent) and fluoroquinolone (a topoisomerase inhibitororganisms are exposed to the DNA damaging agents UV irradiation, bleomycin or mitomycin C, species-specific cellular aggregation is induced. In S. acidocaldariussurgery resulted in better vision or quality of life. The additional use of mitomycin C is of unclear effect. Radiotherapy has also been used in an attemptMitobronitol Pipobroman Triazenes (Dacarbazine# Mitozolomide§ Temozolomide) Intercalation Streptomyces (Dactinomycin# Bleomycin# Mitomycins Plicamycin)Mitobronitol Pipobroman Triazenes (Dacarbazine# Mitozolomide§ Temozolomide) Intercalation Streptomyces (Dactinomycin# Bleomycin# Mitomycins Plicamycin)Methylmercuric dicyanamide Methyltrichlorosilane Metolcarb Mevinphos Mexacarbate Mitomycin C Monocrotophos Muscimol Mustard gas Nickel carbonyl Nicotine Nicotine"Long-term efficacy of maintenance bacillus Calmette-Guérin versus maintenance mitomycin C instillation therapy in frequently recurrent TaT1 tumours without carcinomaproducers. Ciba Found Symp. 171:199-214. Iyer VN, Szybalski W. 1964. Mitomycins and porfiromycin: chemical mechanism of activation and cross-linking of(Mithracin) (1970) Bleomycin (Blenoxane) (1973) Doxorubicin (Adriamycin) (1974) Mitomycin C (Mutamycin) (1974) L-Asparaginase (Elspar) (1978) Daunomycin (Cerubidine)exposed to DNA-damaging UV irradiation or to the agents bleomycin or mitomycin C, species-specific cellular aggregation is induced. Aggregation in Sare sensitive to drugs that treat cancer by DNA crosslinking, such as mitomycin C. The typical age of death was 30 years in 2000. FA occurs in about onedissociated into single cells, and plated on fibroblasts treated with mitomycin-c (to prevent fibroblast mitosis). Clonal cell lines are created by growingMitobronitol Pipobroman Triazenes (Dacarbazine# Mitozolomide§ Temozolomide) Intercalation Streptomyces (Dactinomycin# Bleomycin# Mitomycins Plicamycin)of indolequinones and the related mitosenes include natural compound mitomycin and the related chemotherapeutic agent apaziquone. Indolequinones at theMitobronitol Pipobroman Triazenes (Dacarbazine# Mitozolomide§ Temozolomide) Intercalation Streptomyces (Dactinomycin# Bleomycin# Mitomycins Plicamycin)(2015). "Biodegradable 3D-Porous Collagen Matrix (Ologen) Compared with Mitomycin C for Treatment of Primary Open-Angle Glaucoma: Results at 5 Years". Jof this condition, mice were treated with the chemotherapeutic agent mitomycin C. In the prefrontal cortex, this treatment resulted in an increase ofresection of the tumor, but recurrence is common. Some patients are given mitomycin into the bladder either as a one-off dose in the immediate post-operativeMethylamine 1.469 (neutral amine) 1.499 (ammonium salt) Aziridines 1 CH2NHCH2 Mitomycin 1.472 Azides 1 R2C-N3 phenyl azide Anilines 1 Ph-NH2 Anisidine 1.355 (sp2REGPARA Oncology medicines ABSTRAL GRAN / Peglasta / Neulasta LEUNASE Mitomycin-C SANCUSO Diagnostics In vitro diagnostic reagents, analyzers and companionMitobronitol Pipobroman Triazenes (Dacarbazine# Mitozolomide§ Temozolomide) Intercalation Streptomyces (Dactinomycin# Bleomycin# Mitomycins Plicamycin)Cunningham D, et al. (April 2002). "Prospective randomized trial comparing mitomycin, cisplatin, and protracted venous-infusion fluorouracil (PVI 5-FU) WithMitobronitol Pipobroman Triazenes (Dacarbazine# Mitozolomide§ Temozolomide) Intercalation Streptomyces (Dactinomycin# Bleomycin# Mitomycins Plicamycin)ifosfamide, irinotecan, ixabepilone, letrozole, lomustine, megestrol, mitomycin, mitoxantrone, paclitaxel, procarbazine, tamoxifen, topotecan Some antidepressantsmeasures using anti-fibrotic medication like 5-fluorouracil (5FU) or Mitomycin-C (during the procedure), or creating a necessity for revision surgeryMitobronitol Pipobroman Triazenes (Dacarbazine# Mitozolomide§ Temozolomide) Intercalation Streptomyces (Dactinomycin# Bleomycin# Mitomycins Plicamycin)Mitobronitol Pipobroman Triazenes (Dacarbazine# Mitozolomide§ Temozolomide) Intercalation Streptomyces (Dactinomycin# Bleomycin# Mitomycins Plicamycin)chemotherapy agents such as fenretinide, vinblastine, irinotecan and mitomycin C can dramatically potentiate their antitumor effects. Currently in Phasesurface. Chemotherapy (typically utilising the chemotherapeutic agent Mitomycin C) may be infused directly into the abdominal cavity after cytoreductive
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