Doublecortin


Doublecortin (DCX) is a microtubule -associated protein expressed by neuronal precursor cells and immature neurons in embryonic and adult cortical structures. Neuronal precursor cells begin to express DCX while actively dividing, and their neuronal daughter cells continue to express DCX for 2-3 weeks as the cells mature into neurons.

Doublecortin (DCX) is mutated in X-linked lissencephaly and is the major genetic cause of subcortical band heterotopia (Dobyns and Truwit, 1995 ). DCX is a microtubule-associated protein that interacts with and stabilizes polymerized microtubules ( des Portes et al., 1998; Gleeson et al., 1998; Francis et al., 1999; Horesh et al., 1999 ).

Doublecortin maintains bipolar shape and nuclear translocation during migration in the adult forebrain. Nat. Neurosci. 9, 779-786. 10.1038/nn1704 [Google Scholar] Koizumi H., Tanaka T., Gleeson J. G. (2006b). Doublecortin-like kinase functions with doublecortin to mediate fiber tract decussation and neuronal migration.

Doublecortin (DCX) is a microtubule-associated protein that has been considered a marker for neuronal precursors and young migrating neurons during the development of the central nervous system and in adult neurogenic niches. The retina of fishes represents an accessible, continuously growing and highly structured (layered) part of the central ...

Recently, we and others reported that the doublecortin gene is responsible for X-linked lissencephaly and subcortical laminar heterotopia. Here, we show that Doublecortin is expressed in the brain throughout the period of corticogenesis in migrating and differentiating neurons. Immunohistochemical s 鈥

Doublecortin is expressed in differentiated projection neurons. Finally, Vellema et al. (2014) report that DCX is expressed in neurons that have established functional connectivity and have, therefore, presumably been mature for a significant period of time. In three birds the authors labeled some DCX-expressing neurons in HVC by injecting a ...

Doublecortin (DCX) is a 40 kDa microtubule-associated protein (MAP) that is expressed in a precise temporal manner in migrating neuroblasts during early embryonic development. It is also retained in neurogenic areas in the adult (the subventricular zone (SVZ) ...

Doublecortin, a brain speci铿乧 gene mutated in human X-linked lissencephaly and double cortex syndrome, encodes a puta-tive signaling protein. Cell 1998; 92: 63-72.

Doublecortin (DCX) is a microtubule-associated protein that is critical for neuronal migration and the development of the cerebral cortex. In the adult, it is expressed in newborn neurons in the subventricular and subgranular zones, but not in the mature neurons of the cerebral cortex. By contrast, neurogenesis and neuronal migration of cells ...

Doublecortin (DCX) is a protein that regulates microtubule stability and neuronal migration in the developing brain. It is also involved in cancer cell migration and invasion, and its gene mutations can cause neurological disorders like lissencephaly and subcortical band heterotopia.

Doublecortin domains are found in a wide variety of genes and are involved in mediating protein-protein interactions. Alternatively spliced transcript variants encoding distinct isoforms of DCDC5 have been found, but the full-length nature of such variants is not determined. Genes which contain these domains are highly expressed in the ...

Doublecortin (DCX) is a microtubule (MT)-associated protein that regulates MT structure and function during neuronal development and mutations in DCX lead to a spectrum of neurological disorders.

For instance, doublecortin (DCX) and doublecortin鈥恖ike kinase 1 (DCLK1) interact with microtubules and have been implicated in microtubule鈥恇ased transport processes (Tanaka et al, 2004; Liu et al, 2012). However, the role of specific microtubule鈥恇inding proteins in regulating polarized cargo transport in neurons has not been investigated.

Recently, we and others reported that the doublecortin gene is responsible for X-linked lissencephaly and subcortical laminar heterotopia. Here, we show that Doublecortin is expressed in the brain throughout the period of corticogenesis in migrating and differentiating neurons. Immunohistochemical studies show its localization in the soma and leading processes of tangentially migrating neurons ...

Doublecortin is a microtubule-associated protein that was first studied in a neuroscience context due to its role in neurogenic processes and as a neuronal migration marker.23,39 Doublecortin is released by injured beta cells when discharged from intracellular to extracellular space. Thus, doublecortin has strong beta-cell selectivity and is ...

The microtubule associated protein Doublecortin (DCX) is expressed by migrating neuroblasts and immature neurons, and is widely used as a stage-specific marker of adult neurogenesis and as a marker to identify neurogenic activity in the adult brain per se. Mutations in the DCX gene have been causally linked to human lissencephalic syndromes ...

Doublecortin (DCX) is required for normal migration of neurons into the cerebral cortex, since mutations in the human gene cause a disruption of cortical neuronal migration. To date, little is known about the distribution of DCX protein or its function. Here, we demonstrate that DCX is expressed in migrating neurons throughout the central and peripheral nervous system during embryonic and ...

In line with recent reports, we detected many doublecortin-positive (DCX +) neurons among CA1 neurons, DGGC and interneurons 34 (Fig. 4d and Extended Data Fig. 8), and found that the conserved ...

DCX (Doublecortin) is a Protein Coding gene. Diseases associated with DCX include Lissencephaly, X-Linked, 1 and Band Heterotopia.Among its related pathways are Nervous system development and L1CAM interactions.Gene Ontology (GO) annotations related to this gene include protein kinase binding and calmodulin binding.An important paralog of this gene is MAPKAPK2.

The levels of doublecortin, that is used as a marker for immature neurons, were the lowest in the OB of aged female opossums. Another protein, HuD that is associated with learning and memory, was ...

Doublecortin (DCX) is a microtubule (MT)-stabilizing protein essential for neuronal migration during human brain development. Missense mutations in DCX cause severe brain defects. This implies that the many other MT-stabilizing proteins in neurons cannot compensate for DCX function. To understand the unusual properties of DCX, we expressed the ...

Our data revealed individual differences in the levels of doublecortin in relation to memory performance across aged opossums. These differences were correlated with distinct behaviors, particularly, aged opossums with high levels of DCX achieved high performance levels in the water maze task. We, therefore suggest that new neurons in the DG of ...

For instance, doublecortin (DCX) and doublecortin鈥恖ike kinase 1 (DCLK1) interact with microtubules and have been implicated in microtubule鈥恇ased transport processes (Tanaka et al, 2004; Liu et al, 2012). However, the role of specific microtubule鈥恇inding proteins in regulating polarized cargo transport in neurons has not been investigated.

The DCX gene provides instructions for producing a protein called doublecortin. This protein is involved in the movement of nerve cells (neurons) to their proper locations in the developing brain, a process called neuronal migration. Doublecortin attaches (binds) to microtubules, which are rigid, hollow fibers that make up the cell's structural ...

In this study, we set out to understand whether JIP3 activates dynein using in vitro motility assays. We then investigated the molecular basis of JIP3-dependent activation by visualizing these complexes, bound to microtubules in the presence of the nonhydrolyzable adenosine triphosphate analog adenylyl-imidodiphosphate (AMP-PNP), using cryo-electron microscopy.

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migration protein doublecortin, also known as doublin or lissencephalin-X is a protein that in humans is encoded by the DCX gene. Doublecortin (DCX) is aand a mutation in this gene has been reported. DCX or doublecortin encodes for the doublecortin protein which is similar to LIS1 as it encodes a microtubuleTruncated (shortened) mutations of LIS1 tend to cause severe lissencephaly. Doublecortin (DCX or XLIS) mutations are responsible for X-linked disorders. WhileDoublecortin like kinase 3 is a protein that in humans is encoded by the DCLK3 gene. GRCh38: Ensembl release 89: ENSG00000163673 - Ensembl, May 2017 GRCm38:granule cell layer (GCL), and molecular layer (ML). Cells were stained for doublecortin (DCX). (B) Closeup of subgranular zone, located between the hilus andis similar to doublecortin (DCX)". Genomics. 56 (1): 121鈥6. doi:10.1006/geno.1998.5718. PMID聽10036192. "Entrez Gene: DCAMKL1 doublecortin and CaM kinase-likespacecraft Digital customer experience DCX (gene), which encodes the protein doublecortin .dcx (DCX), a document image format, the Multipage PCX 610 (number) (Romanunknown. Oleamide has been found to enhance PPAR伪-dependent increase in doublecortin, a marker of neurogenesis in the hippocampus Oleamide is rapidly metabolizedbeen shown to harbor cells expressing markers of plasticity such as doublecortin and PSA-NCAM which are modulated by the noradrenergic neurotransmittergranule cell layer (GCL), and molecular layer (ML). Cells were stained for doublecortin (DCX), a protein expressed by neuronal precursor cells and immature neuronsbullosa, dystrophic, dominant and recessive) CRBN: Cereblon protein DCLK3: Doublecortin like kinase 3 DLEC1: encoding protein Deleted in lung and esophagealhelp from a specialised team or health professional.[citation needed] Doublecortin positive cells, similar to stem cells, are extremely adaptable and, whennucleation potential of centrosomes. The microtubule-binding protein doublecortin, in vitro, nucleates microtubules鈥攁cting by binding to the side ratherS. A.; Ramanujam, R; Wyche, J. H.; Anant, S; Houchen, C. W. (2009). "Doublecortin and CaM kinase-like-1 and leucine-rich-repeat-containing G-protein-coupledTelencephalon and Cerebellar Cortex of the Nile Crocodile Revealed with Doublecortin Immunohistochemistry: ADULT NEUROGENESIS IN NILE CROCODILE". The Anatomicalneurons mature, typically after they have downregulated expression of Doublecortin, a marker seen in the earliest stages of neuronal development. Fox-3Doublecortin domain-containing protein 2 (DCDC2) is a protein that in humans is encoded by the DCDC2 gene. This gene encodes a protein with two doublecortinhave been used in birds include NeuN, Hu, PCNA, pHH3, and DCX. DCX (doublecortin) is one of the most commonly used protein target when describing neurogenesispromoter. For example, a recombinant plasmid may contain the promoter for doublecortin, a protein expressed predominantly by neurons, upstream of a sequenceof symptoms. The scientific classifications for these types include: Doublecortin positive cells, similar to stem cells, are extremely adaptable and, whendendritic proteins into axons. On the other hand, DCX encodes the protein doublecortin that interacts with Lis1 on top of supporting the 13 protofilament structureAnother protein that contributes to a lissencephaly disorder is DCX, or Doublecortin. DCX is a microtubule associated protein that is responsible for doublecortical layers, Magavi showed that SVZ neural progenitors expressing Doublecortin, a critical molecule for migration of neuroblasts, migrated long distancesthere are specific markers that label particular regions of the neuron. Doublecortin (DCX) is a microtubule-associated protein that is widely expressed inMinnerath, Sharon R; Ross, M.Elizabeth; Walsh, Christopher A (1998). "doublecortin, a Brain-Specific Gene Mutated in Human X-Linked Lissencephaly and DoublePMID聽23144223. Schaar, BT; Kinoshita, K; McConnell, SK (22 January 2004). "Doublecortin microtubule affinity is regulated by a balance of kinase and phosphataseThis gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains that bind to microtubules andof catastrophe without affecting the promotion of microtubule growth. Doublecortin (DCX) shows an ability to inhibit catastrophe without affecting the microtubuleKizhatil K, Wu YX, Sen A, Bennett V (September 2002). "A new activity of doublecortin in recognition of the phospho-FIGQY tyrosine in the cytoplasmic domainwith DYNC1H1, CLIP1, NDEL1, NDE1,PAFAH1B3, PAFAH1B2, NUDC, TUBA1A and Doublecortin. platelet-activating factor PAFAH1B2 PAFAH1B3 GRCh38: Ensembl release1 and regulates the microtubules by also phosphorylating tau, MAP1B, doublecortin, Nudel, and CRMPs, which are all microtubule-associated proteins. A non-properKapitein LC, Jaworski J, Hoogenraad CC (2016). "Microtubule-binding protein doublecortin-like kinase 1 (DCLK1) guides kinesin-3-mediated cargo transport to dendrites"Oldekamp J, Eichele G (2004). "Identification of neurabin II as a novel doublecortin interacting protein". Mech. Dev. 120 (9): 1033鈥43. doi:10.1016/S0925-4773(03)00177-1G, Perez-Garcia CG, Gleeson JG (Nov 2002). "Selective expression of doublecortin and LIS1 in developing human cortex suggests unique modes of neuronalVinet MC, Schaar BT, McConnell SK, Francis F, Chelly J (Sep 2001). "Doublecortin interacts with mu subunits of clathrin adaptor complexes in the developingsignificantly decreased 48 hours after irradiation. Antibodies against Ki-67 and doublecortin (Dcx) were used to detect proliferating cells and immature neurons, respectivelymicrotubule lattice. Three MAPs that localize within dendrites, doublecortin (DCX), doublecortin-like kinase-1 (DCLK1), and MAP9, regulate motor protein activitytreatment or JDP2 is also regulated by other kinases such as p38 MAPK and doublecortin like protein kinase. Polyubiquitination of JDP2 protein is induced byor during autopsies. They discovered that cells that expressed DCX (doublecortin) and PSA-NCAM are present in the brain sections taken from infants, but

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