20 results found for: “ras_protein”.

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Ras GTPase

Ras is a family of related proteins which is expressed in all animal cell lineages and organs. All Ras protein family members belong to a class of protein...

Last Update: 2020-12-01T23:07:10Z Word Count : 3280 Synonim Ras GTPase

KRAS

KRAS gene provides instructions for making a protein called K-Ras, part of the RAS/MAPK pathway. The protein relays signals from outside the cell to the...

Last Update: 2021-02-07T14:28:17Z Word Count : 4195 Synonim KRAS

HRAS

HRas is a small G protein in the Ras subfamily of the Ras superfamily of small GTPases. Once bound to Guanosine triphosphate, H-Ras will activate a Raf...

Last Update: 2021-01-30T02:52:51Z Word Count : 1325 Synonim HRAS

RAS p21 protein activator 1

RAS p21 protein activator 1 or RasGAP (Ras GTPase activating protein), also known as RASA1, is a 120-kDa cytosolic human protein that provides two principal...

Last Update: 2021-01-02T03:19:00Z Word Count : 1590 Synonim RAS p21 protein activator 1

GTPase-activating protein

as RhoA, Rac1, and Rac2. The GAPs that act on small GTP-binding proteins of the Ras superfamily have conserved structures and use similar mechanisms...

Last Update: 2021-01-17T20:46:29Z Word Count : 2234 Synonim GTPase-activating protein

MRAS

Ras-related protein M-Ras, also known as muscle RAS oncogene homolog and R-Ras3, is a protein that in humans is encoded by the MRAS gene on chromosome...

Last Update: 2020-12-14T17:48:41Z Word Count : 2570 Synonim MRAS

Ras p21 protein activator 2

RAS p21 protein activator 2 is a protein that in humans is encoded by the RASA2 gene. The protein encoded by this gene is member of the GAP1 family of...

Last Update: 2020-12-23T15:54:21Z Word Count : 219 Synonim Ras p21 protein activator 2

Oncogene

target protein. They can cause cancer by turning the receptor permanently on (constitutively), even without signals from outside the cell. Ras is a small...

Last Update: 2021-01-06T20:47:00Z Word Count : 2123 Synonim Oncogene

RASGRF1

Ras protein-specific guanine nucleotide-releasing factor 1 is a protein in humans that is encoded by the RASGRF1 gene. The protein encoded by this gene...

Last Update: 2017-11-01T12:19:02Z Word Count : 184 Synonim RASGRF1

Farnesyltransferase inhibitor

drugs that target protein farnesyltransferase with the downstream effect of preventing the proper functioning of the Ras (protein), which is commonly...

Last Update: 2020-12-05T17:55:21Z Word Count : 1079 Synonim Farnesyltransferase inhibitor

SYNGAP1

Synaptic Ras GTPase-activating protein 1, also known as synaptic Ras-GAP 1 or SYNGAP1, is a protein that in humans is encoded by the SYNGAP1 gene. SYNGAP1...

Last Update: 2020-12-14T01:13:58Z Word Count : 2241 Synonim SYNGAP1

MAPK/ERK pathway

The MAPK/ERK pathway (also known as the Ras-Raf-MEK-ERK pathway) is a chain of proteins in the cell that communicates a signal from a receptor on the...

Last Update: 2020-12-20T03:19:16Z Word Count : 2645 Synonim MAPK/ERK pathway

Ras superfamily

The Ras superfamily is a protein superfamily of small GTPases. Members of the superfamily are divided into families and subfamilies based on their structure...

Last Update: 2020-12-05T10:41:43Z Word Count : 285 Synonim Ras superfamily

SH3 domain

several other protein families such as: PI3 Kinase, Ras GTPase-activating protein, CDC24 and cdc25. SH3 domains are found in proteins of signaling pathways...

Last Update: 2021-01-07T00:14:40Z Word Count : 915 Synonim SH3 domain

Rap GTP-binding protein

GTP-binding protein also known as Ras-related proteins or simply RAP is a type of small GTPase, similar in structure to Ras. These proteins share approximately...

Last Update: 2020-12-05T14:23:49Z Word Count : 197 Synonim Rap GTP-binding protein

Neurofibromin 1

neurofibromin, a GTPase-activating protein that negatively regulates RAS/MAPK pathway activity by accelerating the hydrolysis of Ras-bound GTP. NF1 has a high...

Last Update: 2021-02-06T23:17:34Z Word Count : 5853 Synonim Neurofibromin 1

SHC1

kinase to the RAS pathway. The protein SHC1 also acts as a scaffold protein which is used in cell surface receptors. The three proteins that SHC1 codes...

Last Update: 2020-12-10T20:24:52Z Word Count : 1623 Synonim SHC1

RASAL3

RAS protein activator like 3 is a protein that in humans is encoded by the RASAL3 gene. GRCh38: Ensembl release 89: ENSG00000105122 - Ensembl, May 2017...

Last Update: 2021-01-03T04:04:26Z Word Count : 132 Synonim RASAL3

Small GTPase

The best-known members are the Ras GTPases and hence they are sometimes called Ras subfamily GTPases. A typical G-protein is active when bound to GTP and...

Last Update: 2020-12-02T21:10:44Z Word Count : 495 Synonim Small GTPase

Ran (protein)

Ran (RAs-related Nuclear protein) also known as GTP-binding nuclear protein Ran is a protein that in humans is encoded by the RAN gene. Ran is a small...

Last Update: 2021-01-12T05:55:55Z Word Count : 1915 Synonim Ran (protein)

Main result

Ras GTPase

Ras is a family of related proteins which is expressed in all animal cell lineages and organs. All Ras protein family members belong to a class of protein called small GTPase, and are involved in transmitting signals within cells (cellular signal transduction). Ras is the prototypical member of the Ras superfamily of proteins, which are all related in 3D structure and regulate diverse cell behaviours. When Ras is 'switched on' by incoming signals, it subsequently switches on other proteins, which ultimately turn on genes involved in cell growth, differentiation and survival. Mutations in ras genes can lead to the production of permanently activated Ras proteins. As a result, this can cause unintended and overactive signaling inside the cell, even in the absence of incoming signals. Because these signals result in cell growth and division, overactive Ras signaling can ultimately lead to cancer. The 3 Ras genes in humans (HRas, KRas, and NRas) are the most common oncogenes in human cancer; mutations that permanently activate Ras are found in 20% to 25% of all human tumors and up to 90% in certain types of cancer (e.g., pancreatic cancer). For this reason, Ras inhibitors are being studied as a treatment for cancer and other diseases with Ras overexpression.


ras_protein
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