20 results found for: “mitomycin_c”.

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Mitomycin C

Mitomycin C is a mitomycin that is used as a chemotherapeutic agent by virtue of its antitumour activity. It is given intravenously to treat upper gastro-intestinal...

Last Update: 2021-02-23T20:32:20Z Word Count : 1366 Synonim Mitomycin C

Mitomycins

lavendulae. They include mitomycin A, mitomycin B, and mitomycin C. When the name mitomycin occurs alone, it usually refers to mitomycin C, its international...

Last Update: 2021-01-19T12:59:01Z Word Count : 977 Synonim Mitomycins

Glaucoma

Casuccio A, Di Pace F, Cagini C, Ferraro LL, Cillino G (March 2016). "Biodegradable collagen matrix implant versus mitomycin-C in trabeculectomy: five-year...

Last Update: 2021-03-05T19:20:35Z Word Count : 10135 Synonim Glaucoma

Streptococcus pneumoniae

Competence in S. pneumoniae is induced by DNA-damaging agents such as mitomycin C, fluoroquinolone antibiotics (norfloxacin, levofloxacin and moxifloxacin)...

Last Update: 2021-02-24T13:46:02Z Word Count : 2424 Synonim Streptococcus pneumoniae

Antimetabolite

anthracyclines include: Actinomycin-D Bleomycin Mitomycin-C Mitoxantrone Phototrexate Antimetabolites, particularly mitomycin C (MMC), are commonly used in America...

Last Update: 2021-01-21T14:40:05Z Word Count : 1316 Synonim Antimetabolite

Crosslinking of DNA

vitiligo. Mitomycin C (MMC) is from a class of antibiotics that are used broadly in chemotherapy, often with gastrointestinal related cancers. Mitomycin C can...

Last Update: 2020-12-05T08:44:06Z Word Count : 3431 Synonim Crosslinking of DNA

Photorefractive keratectomy

growth factor (NGF) in combination with docosahexaenoic acid (DHA). Mitomycin C worsens post-surgical dry eye. PRK may be performed on one eye at a time...

Last Update: 2021-01-08T12:47:53Z Word Count : 2770 Synonim Photorefractive keratectomy

Trabeculectomy

capsule and the wound bed is treated for several seconds to minutes with mitomycin C (MMC, 0.5–0.2 mg/ml) or 5-fluorouracil (5-FU, 50 mg/ml) soaked sponges...

Last Update: 2021-02-04T21:12:04Z Word Count : 1610 Synonim Trabeculectomy

Fanconi anemia

are sensitive to drugs that treat cancer by DNA crosslinking, such as mitomycin C. The typical age of death was 30 years in 2000. FA occurs in about one...

Last Update: 2021-02-07T10:47:45Z Word Count : 3283 Synonim Fanconi anemia

Pterygium (conjunctiva)

resulted in better vision or quality of life. The additional use of mitomycin C is of unclear effect. Radiotherapy has also been used in an attempt to...

Last Update: 2020-12-22T15:18:08Z Word Count : 2006 Synonim Pterygium (conjunctiva)

Hyperthermic intraperitoneal chemotherapy

time. The chemotherapeutic agents generally infused during IPHC are mitomycin-C and cisplatin. IPHC is generally used after surgical removal of as much...

Last Update: 2020-12-21T19:32:12Z Word Count : 1906 Synonim Hyperthermic intraperitoneal chemotherapy

Bleb (medicine)

(2015). "Biodegradable 3D-Porous Collagen Matrix (Ologen) Compared with Mitomycin C for Treatment of Primary Open-Angle Glaucoma: Results at 5 Years". J...

Last Update: 2020-12-11T19:08:16Z Word Count : 363 Synonim Bleb (medicine)

Bladder cancer

PMID 17719169. Di Stasi SM, Riedl C (June 2009). "Updates in intravesical electromotive drug administration of mitomycin-C for non-muscle invasive bladder...

Last Update: 2021-02-27T20:36:36Z Word Count : 12955 Synonim Bladder cancer

Thermophile

are exposed to the DNA damaging agents UV irradiation, bleomycin or mitomycin C, species-specific cellular aggregation is induced. In S. acidocaldarius...

Last Update: 2020-11-30T00:14:13Z Word Count : 937 Synonim Thermophile

Aziridines

ethylene imine), with molecular formula C 2H 4NH. Several drugs feature aziridine rings, including mitomycin C, porfiromycin, and azinomycin B (carzinophilin)...

Last Update: 2021-02-17T18:15:20Z Word Count : 1625 Synonim Aziridines

Paraxanthine

or theophylline when coadministered with mitomycin C, but not for paraxanthine coadministered with mitomycin C. Paraxanthine was reported to be significantly...

Last Update: 2021-02-04T08:32:21Z Word Count : 2057 Synonim Paraxanthine

Natural competence

instance, Claverys et al. in 2006 showed that the DNA damaging agents mitomycin C (a DNA cross-linking agent) and fluoroquinolone (a topoisomerase inhibitor...

Last Update: 2021-02-14T19:17:24Z Word Count : 2641 Synonim Natural competence

EPA list of extremely hazardous substances

Methylmercuric dicyanamide Methyltrichlorosilane Metolcarb Mevinphos Mexacarbate Mitomycin C Monocrotophos Muscimol Mustard gas Nickel carbonyl Nicotine Nicotine...

Last Update: 2021-01-16T19:02:09Z Word Count : 810 Synonim EPA list of extremely hazardous substances

Streptomyces caespitosus

Streptomyces caespitosus is a species of actinobacteria. It produces chemotherapeutic drug mitomycin C. https://www.uniprot.org/taxonomy/53502...

Last Update: 2021-02-24T13:48:14Z Word Count : 19 Synonim Streptomyces caespitosus

Chemotherapy

anthracyclines and the bleomycins; other prominent examples include mitomycin C and actinomycin. Among the anthracyclines, doxorubicin and daunorubicin...

Last Update: 2021-03-03T21:06:06Z Word Count : 16648 Synonim Chemotherapy

Main result

Mitomycin C

Mitomycin C is a mitomycin that is used as a chemotherapeutic agent by virtue of its antitumour activity. It is given intravenously to treat upper gastro-intestinal cancers (e.g. esophageal carcinoma), anal cancers, and breast cancers, as well as by bladder instillation for superficial bladder tumours. It causes delayed bone marrow toxicity and therefore it is usually administered at 6-weekly intervals. Prolonged use may result in permanent bone-marrow damage. It may also cause lung fibrosis and renal damage. Mitomycin C has also been used topically rather than intravenously in several areas. The first is cancers, particularly bladder cancers and intraperitoneal tumours. It is now well known that a single instillation of this agent within 6 hours of bladder tumor resection can prevent recurrence. The second is in eye surgery where mitomycin C 0.02% is applied topically to prevent scarring during glaucoma filtering surgery and to prevent haze after PRK or LASIK; mitomycin C has also been shown to reduce fibrosis in strabismus surgery. The third is in esophageal and tracheal stenosis where application of mitomycin C onto the mucosa immediately following dilatation will decrease re-stenosis by decreasing the production of fibroblasts and scar tissue. Mitomycin C is a potent DNA crosslinker. A single crosslink per genome has shown to be effective in killing bacteria. This is accomplished by reductive activation of mitomycin to form a mitosene, which reacts successively via N-alkylation of two DNA bases. Both alkylations are sequence specific for a guanine nucleoside in the sequence 5'-CpG-3'. Potential bis-alkylating heterocyclic quinones were synthetised in order to explore their antitumoral activities by bioreductive alkylation. Mitomycin is also used as a chemotherapeutic agent in glaucoma surgery. In the bacterium Legionella pneumophila, mitomycin C induces competence, a condition necessary for the process of natural transformation that transfers DNA and promotes recombination between cells. Exposure of the fruitfly Drosophila melanogaster to mitomycin C increases recombination during meiosis, a key stage of the sexual cycle. It has been suggested that during sexual process in prokaryotes (transformation) and eukaryotes (meiosis) DNA cross-links and other damages introduced by mitomycin C may be removed by recombinational repair.Anticancer treatments with chemotherapeutic agents often impair brain cell function leading to memory loss and cognitive dysfunction. In order to understand the basis of these impairments, mice were treated with mitomycin C, a chemotherapeutic agent, and cells of the prefrontal cortex were examined. This treatment resulted in an increase of the oxidative DNA damage 8-oxo-dG, a decrease in the enzyme OGG1 that ordinarily repairs such damage and epigenetic alterations. These alterations at the DNA level may explain, at least in part, the impairments of cognitive function after chemotherapy.Mitomycin was discovered in the 1950s by Japanese scientists in cultures of the microorganism Streptomyces caespitosus.


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