20 results found for: “dna_helicase”.

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Helicase

for helicases. The human genome codes for 95 non-redundant helicases: 64 RNA helicases and 31 DNA helicases. Many cellular processes, such as DNA replication...

Last Update: 2024-02-03T09:36:54Z Word Count : 6879 Synonim Helicase

DnaB helicase

DnaB helicase is an enzyme in bacteria which opens the replication fork during DNA replication. Although the mechanism by which DnaB both couples ATP...

Last Update: 2024-01-25T02:19:58Z Word Count : 754 Synonim DnaB helicase

Eukaryotic DNA replication

original template strand. To synthesize DNA, the double-stranded DNA is unwound by DNA helicases ahead of polymerases, forming a replication fork containing...

Last Update: 2024-03-25T06:03:10Z Word Count : 14640 Synonim Eukaryotic DNA replication

DNA replication

of an organism. Unwinding of DNA at the origin and synthesis of new strands, accommodated by an enzyme known as helicase, results in replication forks...

Last Update: 2024-03-25T20:48:15Z Word Count : 7306 Synonim DNA replication

T7 DNA helicase

T7 DNA helicase (gp4) is a hexameric motor protein encoded by T7 phages that uses energy from dTTP hydrolysis to process unidirectionally along single...

Last Update: 2023-11-30T03:26:32Z Word Count : 538 Synonim T7 DNA helicase

Okazaki fragments

colleagues. During DNA replication, the double helix is unwound and the complementary strands are separated by the enzyme DNA helicase, creating what is...

Last Update: 2023-12-25T06:05:45Z Word Count : 4435 Synonim Okazaki fragments

Werner syndrome helicase

helicase, also known as DNA helicase, RecQ-like type 3, is an enzyme that in humans is encoded by the WRN gene. WRN is a member of the RecQ Helicase family...

Last Update: 2024-03-24T22:32:01Z Word Count : 3665 Synonim Werner syndrome helicase

Minichromosome maintenance

The minichromosome maintenance protein complex (MCM) is a DNA helicase essential for genomic DNA replication. Eukaryotic MCM consists of six gene products...

Last Update: 2022-10-29T22:16:56Z Word Count : 3042 Synonim Minichromosome maintenance

DNA polymerase

generation. Before replication can take place, an enzyme called helicase unwinds the DNA molecule from its tightly woven form, in the process breaking the...

Last Update: 2024-03-23T19:19:15Z Word Count : 7054 Synonim DNA polymerase

Primase

bacteria, primase binds to the DNA helicase forming a complex called the primosome. Primase is activated by the helicase where it then synthesizes a short...

Last Update: 2024-01-25T12:41:55Z Word Count : 2371 Synonim Primase

Mitochondrial DNA

machinery is formed by DNA polymerase, TWINKLE and mitochondrial SSB proteins. TWINKLE is a helicase, which unwinds short stretches of dsDNA in the 5' to 3'...

Last Update: 2024-03-21T18:14:21Z Word Count : 9952 Synonim Mitochondrial DNA

PIF1 5'-to-3' DNA helicase

PIF1 5'-to-3' DNA helicase is a protein that in humans is encoded by the PIF1 gene. This gene encodes a DNA-dependent adenosine triphosphate (ATP)-metabolizing...

Last Update: 2023-03-04T02:04:27Z Word Count : 541 Synonim PIF1 5'-to-3' DNA helicase

Werner syndrome

resembling members of the RecQ helicases. RecQ helicases are a special type of helicase that function at unique times during DNA repair of doubled stranded...

Last Update: 2024-02-01T22:19:25Z Word Count : 4341 Synonim Werner syndrome

Bloom syndrome protein

DNA helicases and has both DNA-stimulated ATPase and ATP-dependent DNA helicase activities. Mutations causing Bloom syndrome delete or alter helicase...

Last Update: 2024-03-25T08:31:30Z Word Count : 2984 Synonim Bloom syndrome protein

Twinkle (protein)

Twinkle protein also known as twinkle mtDNA helicase is a mitochondrial protein that in humans is encoded by the TWNK gene (also known as C10orf2 or PEO1)...

Last Update: 2024-02-01T21:54:46Z Word Count : 1860 Synonim Twinkle (protein)

RecQ helicase

recombination and DNA repair. RecQ family members share three regions of conserved protein sequence referred to as the: N-terminal – Helicase middle – RecQ-conserved...

Last Update: 2022-10-18T21:26:07Z Word Count : 1881 Synonim RecQ helicase

ATP synthase

macromolecule within the pore; the DNA helicases use the helical shape of DNA to drive their motion along the DNA molecule and to detect supercoiling...

Last Update: 2024-02-13T08:46:26Z Word Count : 3749 Synonim ATP synthase

DNA mismatch repair

activation by the MutS-DNA complex, MutH nicks the daughter strand near the hemimethylated site. MutL recruits UvrD helicase (DNA Helicase II) to separate the...

Last Update: 2024-01-05T16:33:30Z Word Count : 4179 Synonim DNA mismatch repair

Chromodomain helicase DNA-binding (CHD) subfamily

Chromodomain helicase DNA-binding (CHD) proteins is a subfamily of ATP-dependent chromatin remodeling complexes (remodelers). All remodelers fall under...

Last Update: 2024-02-22T11:06:20Z Word Count : 756 Synonim Chromodomain helicase DNA-binding (CHD) subfamily

DNA

Topoisomerases are required for many processes involving DNA, such as DNA replication and transcription. Helicases are proteins that are a type of molecular motor...

Last Update: 2024-03-23T19:31:58Z Word Count : 17845 Synonim DNA

Main result

Helicase

Helicases are a class of enzymes thought to be vital to all organisms. Their main function is to unpack an organism's genetic material. Helicases are motor proteins that move directionally along a nucleic acid phosphodiester backbone, separating two hybridized nucleic acid strands (hence helic- + -ase), using energy from ATP hydrolysis. There are many helicases, representing the great variety of processes in which strand separation must be catalyzed. Approximately 1% of eukaryotic genes code for helicases.The human genome codes for 95 non-redundant helicases: 64 RNA helicases and 31 DNA helicases. Many cellular processes, such as DNA replication, transcription, translation, recombination, DNA repair, and ribosome biogenesis involve the separation of nucleic acid strands that necessitates the use of helicases. Some specialized helicases are also involved in sensing of viral nucleic acids during infection and fulfill a immunological function.A helicase is an enzyme that plays a crucial role in the DNA replication and repair processes. Its primary function is to unwind the double-stranded DNA molecule by breaking the hydrogen bonds between the complementary base pairs, allowing the DNA strands to separate. This creates a replication fork, which serves as a template for synthesizing new DNA strands. Helicase is an essential component of cellular mechanisms that ensures accurate DNA replication and maintenance of genetic information. DNA helicase catalyzes regression. RecG and the enzyme PriA work together to rewind duplex DNA, creating a Holliday junction. RecG releases bound proteins and the PriA helicase facilitates DNA reloading to resume DNA replication. RecG replaces the single-strand binding protein (SSB), which regulates the helicase-fork loading sites during fork regression. The SSB protein interacts with DNA helicases PriA and RecG to recover stalled DNA replication forks. These enzymes must bind to the SSB-helicase to be loaded onto stalled forks. Thermal sliding and DNA duplex binding are possibly supported by the wedge domain of RecG's association with the SSB linker. In a regression reaction facilitated by RecG and ATPHollidayjunctions are created for later processing.


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