Clotrimazole/betamethasone dipropionate, sold under the brand name Lotrisone among others, is a topical medication used for the treatment of fungal infections of the feet, groin, and body in people 17 years of age and older. It is a combination of clotrimazole and betamethasone dipropionate. It is applied to the skin.Common side effects include paresthesia, rash, edema, and secondary infections.In 2021, it was the 274th most commonly prescribed medication in the United States, with more than 900,000 prescriptions.