Sequence logo

A sequence logo showing the most conserved bases around the initiation codon from all human mRNAs (Kozak consensus sequence). Note that the initiation codon is not drawn to scale, otherwise the letters AUG would each have a height of 2 bits.

In bioinformatics, a sequence logo is a graphical representation of the sequence conservation of nucleotides (in a strand of DNA/RNA) or amino acids (in protein sequences).[1] A sequence logo is created from a collection of aligned sequences and depicts the consensus sequence and diversity of the sequences. Sequence logos are frequently used to depict sequence characteristics such as protein-binding sites in DNA or functional units in proteins.

  1. ^ Schneider TD; Stephens RM (1990). "Sequence Logos: A New Way to Display Consensus Sequences". Nucleic Acids Res. 18 (20): 6097–6100. doi:10.1093/nar/18.20.6097. PMC 332411. PMID 2172928.