Prostacyclin receptor

PTGIR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4F8K
Identifiers
Aliases	PTGIR, IP, PRIPR, prostaglandin I2 (prostacyclin) receptor (IP), prostaglandin I2 receptor
External IDs	OMIM: 600022 MGI: 99535 HomoloGene: 7496 GeneCards: PTGIR
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.32 Start 46,620,468 bp[1] End 46,625,089 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 A2|7 9.15 cM Start 16,640,415 bp[2] End 16,644,830 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ascending aorta right coronary artery left coronary artery upper lobe of left lung monocyte right lung pericardium vena cava right lobe of thyroid gland left lobe of thyroid gland Top expressed in blood trigeminal ganglion ankle intercostal muscle subcutaneous adipose tissue spleen Paneth cell white adipose tissue bone marrow soleus muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity guanyl-nucleotide exchange factor activity prostacyclin receptor activity Cellular component integral component of membrane cytosol plasma membrane integral component of plasma membrane membrane Biological process negative regulation of platelet-derived growth factor receptor signaling pathway cell-cell signaling G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger response to lipopolysaccharide negative regulation of smooth muscle cell proliferation adenylate cyclase-activating G protein-coupled receptor signaling pathway signal transduction G protein-coupled receptor signaling pathway inflammatory response positive regulation of cytosolic calcium ion concentration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5739 19222 Ensembl ENSG00000160013 ENSMUSG00000043017 UniProt P43119 P43252 RefSeq (mRNA) NM_000960 NM_008967 RefSeq (protein) NP_000951 NP_032993 Location (UCSC) Chr 19: 46.62 – 46.63 Mb Chr 7: 16.64 – 16.64 Mb PubMed search [3] [4]
Wikidata
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The Prostacyclin receptor, also termed the prostaglandin I2 receptor or just IP, is a receptor belonging to the prostaglandin (PG) group of receptors. IP binds to and mediates the biological actions of prostacyclin (also termed Prostaglandin I₂, PGI₂, or when used as a drug, epoprostenol). IP is encoded in humans by the PTGIR gene. While possessing many functions as defined in animal model studies, the major clinical relevancy of IP is as a powerful vasodilator: stimulators of IP are used to treat severe and even life-threatening diseases involving pathological vasoconstriction.