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MRAS

MRAS
Identifiers
AliasesMRAS, M-RAs, R-RAS3, RRAS3, muscle RAS oncogene homolog, NS11
External IDsOMIM: 608435 MGI: 1100856 HomoloGene: 7424 GeneCards: MRAS
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_008624

RefSeq (protein)

NP_032650

Location (UCSC)Chr 3: 138.35 – 138.41 MbChr 9: 99.27 – 99.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ras-related protein M-Ras, also known as muscle RAS oncogene homolog and R-Ras3, is a protein that in humans is encoded by the MRAS gene on chromosome 3.[5][6][7] It is ubiquitously expressed in many tissues and cell types.[8] This protein functions as a signal transducer for a wide variety of signaling pathways, including those promoting neural and bone formation as well as tumor growth.[9][10][11][12] The MRAS gene also contains one of 27 SNPs associated with increased risk of coronary artery disease.[13]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000158186 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032470 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kimmelman A, Tolkacheva T, Lorenzi MV, Osada M, Chan AM (November 1997). "Identification and characterization of R-ras3: a novel member of the RAS gene family with a non-ubiquitous pattern of tissue distribution". Oncogene. 15 (22): 2675–85. doi:10.1038/sj.onc.1201674. PMID 9400994.
  6. ^ Quilliam LA, Castro AF, Rogers-Graham KS, Martin CB, Der CJ, Bi C (August 1999). "M-Ras/R-Ras3, a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras effector AF6". The Journal of Biological Chemistry. 274 (34): 23850–7. doi:10.1074/jbc.274.34.23850. PMID 10446149.
  7. ^ "Entrez Gene: MRAS muscle RAS oncogene homolog".
  8. ^ "BioGPS - your Gene Portal System". biogps.org. Retrieved 2016-10-10.[permanent dead link]
  9. ^ Kimmelman AC, Osada M, Chan AM (April 2000). "R-Ras3, a brain-specific Ras-related protein, activates Akt and promotes cell survival in PC12 cells". Oncogene. 19 (16): 2014–22. doi:10.1038/sj.onc.1203530. PMID 10803462. S2CID 25048933.
  10. ^ Mathieu ME, Faucheux C, Saucourt C, Soulet F, Gauthereau X, Fédou S, Trouillas M, Thézé N, Thiébaud P, Boeuf H (August 2013). "MRAS GTPase is a novel stemness marker that impacts mouse embryonic stem cell plasticity and Xenopus embryonic cell fate". Development. 140 (16): 3311–22. doi:10.1242/dev.091082. PMID 23863483.
  11. ^ Watanabe-Takano H, Takano K, Keduka E, Endo T (February 2010). "M-Ras is activated by bone morphogenetic protein-2 and participates in osteoblastic determination, differentiation, and transdifferentiation". Experimental Cell Research. 316 (3): 477–90. doi:10.1016/j.yexcr.2009.09.028. PMID 19800879.
  12. ^ Young LC, Hartig N, Muñoz-Alegre M, Oses-Prieto JA, Durdu S, Bender S, Vijayakumar V, Vietri Rudan M, Gewinner C, Henderson S, Jathoul AP, Ghatrora R, Lythgoe MF, Burlingame AL, Rodriguez-Viciana P (December 2013). "An MRAS, SHOC2, and SCRIB complex coordinates ERK pathway activation with polarity and tumorigenic growth". Molecular Cell. 52 (5): 679–92. doi:10.1016/j.molcel.2013.10.004. PMID 24211266.
  13. ^ Mega JL, Stitziel NO, Smith JG, Chasman DI, Caulfield MJ, Devlin JJ, Nordio F, Hyde CL, Cannon CP, Sacks FM, Poulter NR, Sever PS, Ridker PM, Braunwald E, Melander O, Kathiresan S, Sabatine MS (June 2015). "Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials". Lancet. 385 (9984): 2264–71. doi:10.1016/S0140-6736(14)61730-X. PMC 4608367. PMID 25748612.