Ras-related protein M-Ras, also known as muscle RAS oncogene homolog and R-Ras3, is a protein that in humans is encoded by the MRASgene on chromosome 3.[5][6][7] It is ubiquitously expressed in many tissues and cell types.[8] This protein functions as a signal transducer for a wide variety of signaling pathways, including those promoting neural and bone formation as well as tumor growth.[9][10][11][12] The MRAS gene also contains one of 27 SNPs associated with increased risk of coronary artery disease.[13]
^Kimmelman AC, Osada M, Chan AM (April 2000). "R-Ras3, a brain-specific Ras-related protein, activates Akt and promotes cell survival in PC12 cells". Oncogene. 19 (16): 2014–22. doi:10.1038/sj.onc.1203530. PMID10803462. S2CID25048933.
^Watanabe-Takano H, Takano K, Keduka E, Endo T (February 2010). "M-Ras is activated by bone morphogenetic protein-2 and participates in osteoblastic determination, differentiation, and transdifferentiation". Experimental Cell Research. 316 (3): 477–90. doi:10.1016/j.yexcr.2009.09.028. PMID19800879.