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HLA-E

HLA-E
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesHLA-E, EA1.2, EA2.1, HLA-6.2, MHC, QA1, major histocompatibility complex, class I, E
External IDsOMIM: 143010 MGI: 2442805 HomoloGene: 134018 GeneCards: HLA-E
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005516

NM_001271005

RefSeq (protein)

NP_005507

n/a

Location (UCSC)Chr 6: 30.49 – 30.49 MbChr 17: 36.42 – 36.42 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

HLA class I histocompatibility antigen, alpha chain E (HLA-E) also known as MHC class I antigen E is a protein that in humans is encoded by the HLA-E gene.[5] The human HLA-E is a non-classical MHC class I molecule that is characterized by a limited polymorphism and a lower cell surface expression than its classical paralogues. The functional homolog in mice is called Qa-1b, officially known as H2-T23.

  1. ^ a b c ENSG00000225201, ENSG00000236632, ENSG00000230254, ENSG00000206493, ENSG00000233904, ENSG00000229252 GRCh38: Ensembl release 89: ENSG00000204592, ENSG00000225201, ENSG00000236632, ENSG00000230254, ENSG00000206493, ENSG00000233904, ENSG00000229252 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000073405 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mizuno S, Trapani JA, Koller BH, Dupont B, Yang SY (Jun 1988). "Isolation and nucleotide sequence of a cDNA clone encoding a novel HLA class I gene". Journal of Immunology. 140 (11): 4024–30. doi:10.4049/jimmunol.140.11.4024. PMID 3131426.