Choline acetyltransferase

Choline acetyltransferase
Identifiers
EC number2.3.1.6
CAS number9012-78-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
CHAT
Protein CHAT PDB 2fy2.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCHAT, CHOACTASE, CMS1A, CMS1A2, CMS6, choline O-acetyltransferase
External IDsOMIM: 118490 MGI: 88392 HomoloGene: 40693 GeneCards: CHAT
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for CHAT
Genomic location for CHAT
Band10q11.23Start49,609,095 bp[1]
End49,665,104 bp[1]
RNA expression pattern
PBB GE CHAT 221197 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_009891

RefSeq (protein)

NP_034021

Location (UCSC)Chr 10: 49.61 – 49.67 MbChr 14: 32.41 – 32.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Choline acetyltransferase (commonly abbreviated as ChAT, but sometimes CAT) is a transferase enzyme responsible for the synthesis of the neurotransmitter acetylcholine. ChAT catalyzes the transfer of an acetyl group from the coenzyme acetyl-CoA to choline, yielding acetylcholine (ACh). ChAT is found in high concentration in cholinergic neurons, both in the central nervous system (CNS) and peripheral nervous system (PNS). As with most nerve terminal proteins, ChAT is produced in the body of the neuron and is transported to the nerve terminal, where its concentration is highest. Presence of ChAT in a nerve cell classifies this cell as a "cholinergic" neuron. In humans, the choline acetyltransferase enzyme is encoded by the CHAT gene.[5]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000070748 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021919 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Strauss WL, Kemper RR, Jayakar P, Kong CF, Hersh LB, Hilt DC, Rabin M (February 1991). "Human choline acetyltransferase gene maps to region 10q11-q22.2 by in situ hybridization". Genomics. 9 (2): 396–8. doi:10.1016/0888-7543(91)90273-H. PMID 1840566.

From Wikipedia, the free encyclopedia · View on Wikipedia

Powered by easy search